National cooperation

Paweł Zajdel, PhD

Department of Medicinal Chemistry, Faculty of Pharmacy, Jagiellonian University Medical College

Scope of research:

  • Searching for new ligands with central nervous system activity
  • Studies on serotonin receptors ligands selectivity

Joint publications:

  1. Zajdel, P.; Partyka, A.; Marciniec, K.; Bojarski, A. J.; Pawlowski, M.; Wesolowska, A. Quinoline- and isoquinoline-sulfonamide analogs of aripiprazole: novel antipsychotic agents? Future. Med. Chem. 20146, 57-75 (
  2. Canale, V.; Guzik, P.; Kurczab, R.; Verdie, P.; Satala, G.; Kubica, B.; Pawlowski, M.; Martinez, J.; Subra, G.; Bojarski, A. J.; Zajdel, P. Solid-supported synthesis, molecular modeling, and biological activity of long-chain arylpiperazine derivatives with cyclic amino acid amide fragments as 5-HT and 5-HT receptor ligands. Eur. J Med. Chem. 201478, 10-22 (
  3. Chlon-Rzepa, G.; Zmudzki, P.; Satala, G.; Duszynska, B.; Partyka, A.; Wrobel, D.; Jastrzebska-Wiesek, M.; Wesolowska, A.; Bojarski, A. J.; Pawlowski, M.; Zajdel, P. New 8-aminoalkyl derivatives of purine-2,6-dione with arylalkyl, allyl or propynyl substituents in position 7, their 5-HT1A, 5-HT2A, and 5-HT7 receptor affinity and pharmacological evaluation. Pharmacol. Rep. 201365, 15-29 (
  4. Grychowska, K.; Marciniec, K.; Canale, V.; Szymiec, M. ; Glanowski, G.; Satala, G.; Maslankiewicz, A.; Pawlowski, M.; Bojarski, A. J.; Zajdel, P. Quinolinesulfonamides of Aryloxy-/Arylthio-ethyl Piperidines: Influence of an Arylether Fragment on 5-HT1A /5-HT7 Receptor Selectivity. Arch. Pharm. (Weinheim). 2013346, 180-188 (
  5. Zajdel, P.; Marciniec, K.; Maslankiewicz, A.; Grychowska, K.; Satala, G.; Duszynska, B.; Lenda, T.; Siwek, A.; Nowak, G.; Partyka, A.; Wrobel, D.; Jastrzebska-Wiesek, M.;  Bojarski, A. J.; Wesolowska, A.; Pawlowski, M. Antidepressant and antipsychotic activity of new quinoline- and isoquinoline-sulfonamide analogs of aripiprazole targeting serotonin 5-HT(1A)/5-HT(2A)/5-HT(7) and dopamine D(2)/D(3) receptors. Eur. J. Med. Chem. 201360, 42-50 (
  6. Zajdel, P.; Marciniec, K.; Maslankiewicz, A.; Satala, G.; Duszynska, B.; Bojarski, A. J.; Partyka, A.; Jastrzebska-Wiesek, M.; Wrobel, D.; Wesolowska, A.; Pawlowski, M. Quinoline- and isoquinoline-sulfonamide derivatives of LCAP as potent CNS multi-receptor-5-HT1A/5-HT2A/5-HT7 and D2/D3/D4-agents: the synthesis and pharmacological evaluation. Bioorg. Med. Chem. 201220, 1545-1556 (
  7. Zajdel, P.; Kurczab, R.; Grychowska, K.; Satała, G.; Pawłowski, M.; Bojarski, A. J. The multiobjective based design, synthesis and evaluation of the arylsulfonamide/amide derivatives of aryloxyethyl- and arylthioethyl- piperidines and pyrrolidines as a novel class of potent 5-HT7 receptor antagonists. Eur. J. Med. Chem. 201256, 348-360
  8. Zajdel, P.; Marciniec, K.; Maslankiewicz, A.; Paluchowska, M. H.; Satala, G.; Partyka, A.; Jastrzebska-Wiesek, M.; Wrobel, D.; Wesolowska, A.; Duszynska, B.; Bojarski, A. J.; Pawlowski, M. Arene- and quinoline-sulfonamides as novel 5-HT(7) receptor ligands. Bioorg. Med. Chem. 201119, 6750-6759 (
  9. Zajdel, P.; Król, J.; Grychowska, K.; Pawłowski, M.; Subra, G.; Nomezine, G.; Martinez, J.; Satała, G.; Bojarski, A. J.; Zhou, Z.; O’Donnel, M. J.; Scott, W. L. Solid-Phase Synthesis of Arylpiperazine Derivatives and Implementation of the Distributed Drug Discovery (D3) . Molecules 201116, 4104-4121 (
  10. Zajdel, P.; Subra, G. ; Verdie, P.; Gabzdyl, E.; Bojarski, A. J.; Duszynska, B.; Martinez, J.; Pawlowski, M. Sulfonamides with the N-alkyl-N’-dialkylguanidine moiety as 5-HT7 receptor ligands. Bioorg. Med. Chem. Lett. 2009, 19, 4827-4831 (
  11. Zajdel, P.; Subra, G. ; Verdie, P.; Bojarski, A. J.; Duszynska, B.; Basista, K.; Obniska, J.; Martinez, J.; Pawlowski, M. The influence of an ethylene spacer on the 5-HT(1A) and 5-HT(2A) receptor affinity of arylpiperazine derivatives of amides with N-acylated amino acids and 3-differently substituted pyrrolidine-2,5-diones. Eur. J. Med. Chem. 2009, 44, 800-808 (

Jadwiga Handzlik, PhD

Department of Technology and Biotechnology of Drugs, Faculty of Pharmacy, Jagiellonian University Medical College

Scope of research:

  • search for new selective agents of 5-HT7 receptors in the group of hydantoin derivatives
  • study of the mechanisms of overcoming the antibiotic resistance by small molecules

Joint publications:

  1. Handzlik, J.; Bojarski, A. J.; Satala, G.; Kubacka, M. ; Sadek, B.; Ashoor, A.; Siwek, A.; Wiecek, M.; Kucwaj, K.; Filipek, B.; Kiec-Kononowicz, K. SAR-studies on the importance of aromatic ring topologies in search for selective 5-HT(7) receptor ligands among phenylpiperazine hydantoin derivatives. Eur. J Med. Chem. 201478, 324-339 (

Professor Jarosław Polański

Department of Organic Chemistry, Institute of Chemistry, University of Silesia

Scope of research:

  • Development of cheminformatic tools based on privileged structural fragments theory and machine learning

Group of Machine Learning Research (head: Jacek Tabor, PhD)

Institute of Computer Science, Faculty of Mathematics and Computer Science, Jagiellonian University

Scope of research:

  • Development of new algorithms for the application in cheminformatic tasks
  • Development of new methods for clustering chemical compounds
  • Development of new tools for ML-based virtual screening

Joint publications:

(1)  Smusz, S.; Czarnecki, W. M.; Warszycki, D.; Bojarski, A. J. Exploiting uncertainty measures in compounds activity prediction using support vector machines. Bioorg. Med. Chem. Lett. 201525, 100-105 (

(2)  Śmieja, M.; Warszycki, D.; Tabor, J.; Bojarski A. J. Asymmetric clustering index in a case study of 5-HT1A receptor ligands. PLoS One 20149, e102069 (


Professor Marek Główka

Crystallography Group, Faculty of Chemistry, Technical University of Lodz

Scope of research:

Examining the structure-activity relationships in compounds active towards receptors from the serotonergic system

Joint publications:

(1)  Lewgowd, W.; Bojarski, A. J.; Szczesio, M.; Olczak, A.; Glowka, M. L.; Mordalski, S.; Stanczak, A. Synthesis and structural investigation of some pyrimido[5,4-c]quinolin-4(3H)-one derivatives with a long-chain arylpiperazine moiety as potent 5-HT(1A/2A) and 5-HT(7) receptor ligands. Eur. J. Med. Chem. 2011, 46, 3348-3361