Publications 2019

1. Kaczor, A.; Witek, K.; Podlewska, S.; Czekajewska, J.; Lubelska, A.; Zeslawska, E.; Nitek, W.; Latacz, G.; Alibert, S.; Pages, J. M.; Karczewska, E.; Kiec-Kononowicz, K.; Handzlik, J., 5-Arylideneimidazolones with Amine at Position 3 as Potential Antibiotic Adjuvants against Multidrug Resistant Bacteria. Molecules 2019, 24 (3), 24030438 (https://www.ncbi.nlm.nih.gov/pubmed/30691112)
2. Slifirski, G.; Krol, M.; Kleps, J.; Ulenberg, S.; Belka, M.; Baczek, T.; Siwek, A.; Stachowicz, K.; Szewczyk, B.; Nowak, G.; Bojarski, A.; Koziol, A. E.; Turlo, J.; Herold, F., Synthesis of novel pyrido[1,2-c]pyrimidine derivatives with rigidized tryptamine moiety as potential SSRI and 5-HT1A receptor ligands. Eur.J.Med.Chem. 2019, 166, 144-158 (https://www.ncbi.nlm.nih.gov/pubmed/30703658)
3. Lazewska, D.; Kurczab, R.; Wiecek, M.; Satala, G.; Kiec-Kononowicz, K.; Handzlik, J., Synthesis and computer-aided analysis of the role of linker for novel ligands of the 5-HT6 serotonin receptor among substituted 1,3,5-triazinylpiperazines. Bioorg.Chem. 2019, 84, 319-325 (https://www.ncbi.nlm.nih.gov/pubmed/30530073).
4. Evenseth, L. M.; Warszycki, D.; Bojarski, A. J.; Gabrielsen, M.; Sylte, I., In Silico Methods for the Discovery of Orthosteric GABAB Receptor Compounds. Molecules 2019, 24 (5), 24050935 (https://www.ncbi.nlm.nih.gov/pubmed/30866507).
5. Vass, M.; Podlewska, S.; de, E. I.; Bojarski, A. J.; Leurs, R.; Kooistra, A. J.; de, G. C., Aminergic GPCR-Ligand Interactions: A Chemical and Structural Map of Receptor Mutation Data. J.Med.Chem. 2019, 62 (8), 3784-3839 (https://www.ncbi.nlm.nih.gov/pubmed/30351004).
6. Jaskowska, J.; Zareba, P.; Sliwa, P.; Pindelska, E.; Satala, G.; Majka, Z., Microwave-Assisted Synthesis of Trazodone and Its Derivatives as New 5-HT1A Ligands: Binding and Docking Studies. Molecules 2019, 24 (8), 24081609 (https://www.ncbi.nlm.nih.gov/pubmed/31018618).
7. Hogendorf, A. S.; Hogendorf, A.; Popiolek-Barczyk, K.; Ciechanowska, A.; Mika, J.; Satala, G.; Walczak, M.; Latacz, G.; Handzlik, J.; Kiec-Kononowicz, K.; Ponimaskin, E.; Schade, S.; Zeug, A.; Bijata, M.; Kubicki, M.; Kurczab, R.; Lenda, T.; Staron, J.; Bugno, R.; Duszynska, B.; Pilarski, B.; Bojarski, A. J., Fluorinated indole-imidazole conjugates: Selective orally bioavailable 5-HT7 receptor low-basicity agonists, potential neuropathic painkillers. Eur.J.Med.Chem. 2019, 170, 261-275 (https://www.ncbi.nlm.nih.gov/pubmed/30904783).
8. Sliwa, P.; Kurczab, R.; Kafel, R.; Drabczyk, A.; Jaskowska, J., Recognition of repulsive and attractive regions of selected serotonin receptor binding site using FMO-EDA approach. J.Mol.Model. 2019, 25 (5), 114-3995 (https://www.ncbi.nlm.nih.gov/pubmed/30955095).
9. Latacz, G.; Lubelska, A.; Jastrzebska-Wiesek, M.; Partyka, A.; Marc, M. A.; Satala, G.; Wilczynska, D.; Kotanska, M.; Wiecek, M.; Kaminska, K.; Wesolowska, A.; Kiec-Kononowicz, K.; Handzlik, J., The 1,3,5-Triazine Derivatives as Innovative Chemical Family of 5-HT6 Serotonin Receptor Agents with Therapeutic Perspectives for Cognitive Impairment. Int.J.Mol.Sci. 2019, 20 (14), 20143420 (https://www.ncbi.nlm.nih.gov/pubmed/31336820).
10. Slifirski, G.; Krol, M.; Kleps, J.; Podsadni, P.; Belka, M.; Baczek, T.; Siwek, A.; Stachowicz, K.; Szewczyk, B.; Nowak, G.; Bojarski, A.; Koziol, A. E.; Turlo, J.; Herold, F., Synthesis of new 5,6,7,8-tetrahydropyrido[1,2-c]pyrimidine derivatives with rigidized tryptamine moiety as potential SSRI and 5-HT1A receptor ligands. Eur.J.Med.Chem. 2019, 180, 383-397 (https://www.ncbi.nlm.nih.gov/pubmed/31325785).
11. Grychowska, K.; Chaumont-Dubel, S.; Kurczab, R.; Koczurkiewicz, P.; Deville, C.; Krawczyk, M.; Pietrus, W.; Satala, G.; Buda, S.; Piska, K.; Drop, M.; Bantreil, X.; Lamaty, F.; Pekala, E.; Bojarski, A. J.; Popik, P.; Marin, P.; Zajdel, P., Dual 5-HT6 and D3 Receptor Antagonists in a Group of 1H-Pyrrolo[3,2-c]quinolines with Neuroprotective and Procognitive Activity. ACS Chem.Neurosci. 2019, 10 (7), 3183-3196 (https://www.ncbi.nlm.nih.gov/pubmed/30896921).
12. Wnuk, A.; Rzemieniec, J.; Staron, J.; Litwa, E.; Lason, W.; Bojarski, A.; Kajta, M., Prenatal Exposure to Benzophenone-3 Impairs Autophagy, Disrupts RXRs/PPARgamma Signaling, and Alters Epigenetic and Post-Translational Statuses in Brain Neurons. Mol.Neurobiol. 2019, 56 (7), 4820-4837 (https://www.ncbi.nlm.nih.gov/pubmed/30402708).
13. Zareba, P.; Jaskowska, J.; Czekaj, I.; Satala, G., Design, synthesis and molecular modelling of new bulky Fananserin derivatives with altered pharmacological profile as potential antidepressants. Bioorg.Med.Chem. 2019, 27 (15), 3396-3407 (https://www.ncbi.nlm.nih.gov/pubmed/31253535).
14. Jastrzebski, S.; Sieradzki, I.; Lesniak, D.; Tabor, J.; Bojarski, A. J.; Podlewska, S., Three-dimensional descriptors for aminergic GPCRs: dependence on docking conformation and crystal structure. Mol.Divers. 2019, 23 (3), 603-613 (https://www.ncbi.nlm.nih.gov/pubmed/30484023).
15. Hogendorf, A. S.; Hogendorf, A.; Kurczab, R.; Kalinowska-Tluscik, J.; Popik, P.; Nikiforuk, A.; Krawczyk, M.; Satala, G.; Lenda, T.; Knutelska, J.; Bugno, R.; Staron, J.; Pietrus, W.; Matloka, M.; Dubiel, K.; Moszczynski-Petkowski, R.; Pieczykolan, J.; Wieczorek, M.; Pilarski, B.; Zajdel, P.; Bojarski, A. J., 2-Aminoimidazole-based antagonists of the 5-HT6 receptor – A new concept in aminergic GPCR ligand design. Eur.J.Med.Chem. 2019, 179, 1-15 (https://www.ncbi.nlm.nih.gov/pubmed/31229883).
16. Zareba, P.; Jaskowska, J.; Sliwa, P.; Satala, G., New dual ligands for the D2 and 5-HT1A receptors from the group of 1,8-naphthyl derivatives of LCAP. Bioorg.Med.Chem.Lett. 2019, 29 (16), 2236-2242 (https://www.ncbi.nlm.nih.gov/pubmed/31253532).
17. Ali, W.; Wiecek, M.; Lazewska, D.; Kurczab, R.; Jastrzebska-Wiesek, M.; Satala, G.; Kucwaj-Brysz, K.; Lubelska, A.; Gluch-Lutwin, M.; Mordyl, B.; Siwek, A.; Nasim, M. J.; Partyka, A.; Sudol, S.; Latacz, G.; Wesolowska, A.; Kiec-Kononowicz, K.; Handzlik, J., Synthesis and computer-aided SAR studies for derivatives of phenoxyalkyl-1,3,5-triazine as the new potent ligands for serotonin receptors 5-HT6. Eur.J.Med.Chem. 2019, 178, 740-751 (https://www.ncbi.nlm.nih.gov/pubmed/31229876).
18. L’Estrade, E. T.; Petersen, I. N.; Xiong, M. F.; Hogendorf, A. S.; Hogendorf, A.; Kristensen, J. L.; Kjær, A.; Bojarski, A. J.; Erlandsson, M.; Ohlsson, T.; Knudsen, G. M.; Herth, M. M., Radiolabeling and in vivo evaluation of C-11 AGH-44: a potential lead structure to develop a positron emission tomography radioligand for the 5-HT7 receptor. J.Radioanal.Nucl.Chem. 2019, 322 (2), 847-851.
19. Wrobel, M. Z.; Chodkowski, A.; Herold, F.; Marciniak, M.; Dawidowski, M.; Siwek, A.; Starowicz, G.; Stachowicz, K.; Szewczyk, B.; Nowak, G.; Belka, M.; Baczek, T.; Satala, G.; Bojarski, A. J.; Turlo, J., Synthesis and biological evaluation of new multi-target 3-(1H-indol-3-yl)pyrrolidine-2,5-dione derivatives with potential antidepressant effect. Eur.J.Med.Chem. 2019, 183, 111736 (https://www.ncbi.nlm.nih.gov/pubmed/31586817).
20. Jankowska, A.; Satala, G.; Partyka, A.; Wesolowska, A.; Bojarski, A. J.; Pawlowski, M.; Chlon-Rzepa, G., Discovery and Development of Non-Dopaminergic Agents for the Treatment of Schizophrenia: Overview of the Preclinical and Early Clinical Studies. Curr.Med.Chem. 2019, 26 (25), 4885-4913 (https://www.ncbi.nlm.nih.gov/pubmed/30691112).
21. Owczarzak, A.; Dutkiewicz, Z.; Kurczab, R.; Pietrus, W.; Kubicki, M.; Grzeskiewicz, A. M., Role of Staple Molecules in the Formation of S center dot center dot center dot S Contact in Thioamides: Experimental Charge Density and Theoretical Studies. Cryst.Growth.Des. 2019, 19 (12), 7324-7335.
22. Kurek, J.; Kwasniewska-Sip, P.; Myszkowski, K.; Cofta, G.; Barczynski, P.; Murias, M.; Kurczab, R.; Sliwa, P.; Przybylski, P., Antifungal, anticancer, and docking studies of colchiceine complexes with monovalent metal cation salts. Chem.Biol.Drug Des. 2019, 94 (5), 1930-1943 (https://www.ncbi.nlm.nih.gov/pubmed/31260187).
23. Kulaga, D.; Jaskowska, J.; Satala, G., Design, synthesis and biological evaluation of novel serotonin and dopamine receptor ligands being 6-bromohexyl saccharine derivatives. Bioorg.Med.Chem.Lett. 2019, 29 (21), 126667 (https://www.ncbi.nlm.nih.gov/pubmed/31547945).
24. Popik, P.; Krawczyk, M.; Kuziak, A.; Bugno, R.; Hogendorf, A.; Staron, J.; Nikiforuk, A., Serotonin type 5A receptor antagonists inhibit D-lysergic acid diethylamide discriminatory cue in rats. J.Psychopharmacol. 2019, 33 (11), 1447-1455 (https://www.ncbi.nlm.nih.gov/pubmed/31452444).
25. Kudla, L.; Bugno, R.; Skupio, U.; Wiktorowska, L.; Solecki, W.; Wojtas, A.; Golembiowska, K.; Zador, F.; Benyhe, S.; Buda, S.; Makuch, W.; Przewlocka, B.; Bojarski, A. J.; Przewlocki, R., Functional characterization of a novel opioid, PZM21, and its effects on the behavioural responses to morphine. Br.J.Pharmacol. 2019, 176 (23), 4434-4445 (https://www.ncbi.nlm.nih.gov/pubmed/31347704).
26. Kurczab, R.; Kucwaj-Brysz, K.; Sliwa, P., The Significance of Halogen Bonding in Ligand-Receptor Interactions: The Lesson Learned from Molecular Dynamic Simulations of the D4 Receptor. Molecules 2019, 25 (1), 25010091 (https://www.ncbi.nlm.nih.gov/pubmed/31881785).
27. Lesniak, D.; Podlewska, S.; Jastrzebski, S.; Sieradzki, I.; Bojarski, A. J.; Tabor, J., Development of New Methods Needs Proper Evaluation-Benchmarking Sets for Machine Learning Experiments for Class A GPCRs. J.Chem.Inf.Model. 2019, 59 (12), 4974-4992 (https://www.ncbi.nlm.nih.gov/pubmed/31604014).