e-mail: kordyl@if-pan.krakow.pl
phone: +4812 66 23 320
Research interests:
- Drug design
- GPCR
- Molecular dynamics simulations
- Serotonin receptors research (currently 5-HT2A mainly)
- Total synthesis
- Phenomenon of residence time and unbinding kinetics
Scientific career:
01.10.2024 – current Doctoral Studies – Maj Institute of Pharmacology Polish Academy of Sciences; studies in Medical and Health Sciences, Specialization – Pharmacological Sciences.
01.10.2020 – 30.07.2022 Master of Science – Jagiellonian University, Faculty of Chemistry; studies in Medical Chemistry. Thesis: Synthesis and biological activity of alkaloid derivatives containing the 2‑aminoimidazole moiety Supervisor: Professor Andrzej Bojarski PhD (IP PAS)
01.10.2018 – 01.06.2021 Bachelor of Science – Jagiellonian University, Faculty of Chemistry; Department of Heterocyclic and Organometallic Chemistry, studies in Medical Chemistry. Thesis: Optimization of the synthesis of a novel metabotropic mGlu7 receptor ligand – LSP4-2022. Supervisor: Professor Dariusz Cież PhD
Publications:
Kordylewski, S. K.; Bugno, R.; Podlewska, S. Residence Time in Drug Discovery: Current Insights and Future Perspectives. Pharmacological Reports 2025. https://doi.org/10.1007/s43440-025-00748-z.
Kordylewski, S. K.; Bugno, R.; Bojarski, A. J.; Podlewska, S. Uncovering the Unique Characteristics of Different Groups of 5-HT5AR Ligands with Reference to Their Interaction with the Target Protein. Pharmacological Reports 2024, 76 (5), 1130–1146. https://doi.org/10.1007/s43440-024-00622-4.
Participation in research projects:
a) as principal investigator:
2026 – current Design and Pharmacological Evaluation of Marine Alkaloid-Inspired Serotonin 5-HT2A Receptors Ligands financed by the grant PRELUDIUM (NCN), No. 2025/57/N/NZ1/04263
b) as executor:
2025 – current GenProSyn – an innovative generative approach to enumeration of easy-to synthesize ligands with optimized properties (Agreement No. FENG.02.02-IP.05-0039/23), FIRST TEAM programme of the Foundation for Polish Science cofinanced by the European Union under the European Funds for Smart Economy 2021−2027 (FENG).
2025 – current OPUS NCN „I Like to Move It, Move It” – Optimization of Ligand Residence Time in the Receptor Based on Molecular Dynamics Simulations as a Strategy to Enhance Pharmacological Activity. 1 661 823,00 NR: PLN 2023/49/B/NZ7/03340
2025 – 04. 2026 ABM Optimization of Bioavailability and Validation of the Therapeutic Potential of Tryptamide in Neurological Disorders 2024/ABM/03/KPO/KPOD.07.07-IW.07-0173/24-00/
01.08.2021 – 01.12.2023 Serotonergic Pain Therapy Based on a 5-HT7 Receptor Agonist (STEP7). The project was implemented by a scientific consortium of associations from the phrmaceutical company Celon Pharma S.A. and the Institute of Pharmacology PAN. 55 612 767,61 PLN POIR.01.01.01-00-0887/19.
Scientific reports:
Speeches:
2025
Oral speech. Kordylewski, S. K.; Bugno, R; Satała, G; Lenda, T; Podlewska, S. Decoding Molecular Determinants of Prolonged Residence Time of 5-HT2A Receptor Ligands – Case Study of Ritanserin Derivatives. 12th Medicinal Chemistry Conference. 11-13.09.2025 Lublin Book of Abstracts, p. 58
Oral speech. Kordylewski, S. K. The Great Escape: Decoding Molecular Determinants of Prolonged Residence Time of 5-HT2A Receptor Ligands – Case of Ritanserin Derivatives” National Eliminations for EFMC-YMCS 2025 in Porto. 10.05.2025 Kraków
2021
Oral speech. Kordylewski, S. K. Optimization of the synthesis of a novel metabotropic mGlu7 receptor ligand – LSP4-2022. 12th International Student Conference “Horizons of Science” 07-08.06.2021 Kraków
Posters:
2026
Poster. Szymon K. Kordylewski, Kinga Kurowska, Krystyna Nędza, Dorota Satała, Ryszard Bugno, Sabina Podlewska. Residence time of 5-HT2A receptor antagonists: new data from studies on ritanserin derivatives. 43rd Winter School of the Maj Institute of Pharmacology PAS. Kraków Book of Abstract, p. 95
2025
Poster. Kordylewski, S. K.; Bugno, R; Satała, G; Lenda, T; Podlewska, S. Key Structural Factors Influencing Long-Lasting 5-HT2A Receptor Interaction Of Ritanserin-Based Compounds. 12th Medicinal Chemistry Conference. 11-13.09.2025 Lublin Book of Abstracts, p. 141
Poster. Kordylewski, S. K.; Kurowska, K.; Bugno, R; Satała, G; Nędza, K; Podlewska, S. Optimization of compound kinetics as a way to improve pharmacological efficacy of serotonin receptor ligands. Workshop: Cognitive affective biases – from mechanisms to disease symptoms. 26-30.05.2025 Tomaszowice
Poster presentation. Kordylewski, S. K.; Bugno, R; Satała, G; Lenda, T; Bojarski A. J; Podlewska, S. The Role of Residence Time in the Design of Serotonin Receptor-Targeted Drugs. 42nd Winter School of the Jerzy Maj Institute of Pharmacology, Polish Academy of Sciences „Chemical and Behavioral Addictions in the 21st Century” 24-26.02.2025 Kraków
2022
Poster presentation. Kordylewski, S. K. 2-aminoimidazole derivatives as 5-HT receptor antagonists. 13th International Student Conference “Horizons of Science” 04-05.06.2022 Kraków
Poster presentation. Kordylewski, S. K. Serotonin and serotonin receptors. 2nd National Student Scientific Conference „Closer to Chemistry” 08-09.01.2022 Kraków Book of Abstracts, p. 91
Experience gained in abroad:
05. 2025 – currently HUN-REN Medicinal Chemistry Research Group https://medchem.ttk.hu/index