e-mail: paluchm@if-pan.krakow.pl
phone: +4812 66 23 319
Scientific career:
Publications:
- Zajdel, P.; Marciniec, K.; Maslankiewicz, A.; Paluchowska, M. H.; Satala, G.; Partyka, A.; Jastrzebska-Wiesek, M.; Wrobel, D.; Wesolowska, A.; Duszynska, B.; Bojarski, A. J.; Pawlowski, M. Arene- and quinoline-sulfonamides as novel 5-HT(7) receptor ligands. Bioorg. Med. Chem. 2011, 19, 6750-6759 (http://www.ncbi.nlm.nih.gov/pubmed/22001327)
- Paluchowska, M. H.; Bugno, R.; Duszynska, B.; Tatarczynska, E.; Nikiforuk, A.; Lenda, T.; Chojnacka-Wojcik, E. The influence of modifications in imide fragment structure on 5-HT(1A) and 5-HT(7) receptor affinity and in vivo pharmacological properties of some new 1-(m-trifluoromethylphenyl)piperazines. Bioorg. Med. Chem. 2007, 15, 7116-7125 (http://www.ncbi.nlm.nih.gov/pubmed/17825569).
- Paluchowska, M. H.; Bugno, R.; Charakchieva-Minol, S.; Bojarski, A. J.; Tatarczynska, E.; Chojnacka-Wojcik, E. Conformational Restriction in Novel NAN-190 and MP3022 Analogs and Their 5-HT(1A) Receptor Activity. Arch. Pharm. (Weinheim) 2006, 339, 498-506 (http://www.ncbi.nlm.nih.gov/pubmed/16941730)
- Bojarski, A. J.; Paluchowska, M. H.; Duszynska, B.; Bugno, R.; Klodzinska, A.; Tatarczynska, E.; Chojnacka-Wojcik, E. Structure-intrinsic activity relationship studies in the group of 1-imido/amido substituted 4-(4-arylpiperazin-1-yl)cyclohexane derivatives; new, potent 5-HT(1A) receptor agents with anxiolytic- like activity. Bioorg. Med. Chem. 2006, 14, 1391-1402 (http://www.ncbi.nlm.nih.gov/pubmed/16266808).
- Bojarski, A. J.; Paluchowska, M. H.; Duszyńska, B.; Kłodzińska, A.; Tatarczyńska, E.; Chojnacka-Wójcik, E. 1-Aryl-4-(4-succinimidobutyl)piperazines and their conformationally constrained analogues: synthesis, binding to serotonin (5-HT1A, 5-HT2A, 5-HT7), α1-adrenergic and dopaminergic D2 receptors, and in vivo 5-HT1A functional characteristics. Bioorg. Med. Chem. 2005, 13, 2293-3303 (http://www.ncbi.nlm.nih.gov/pubmed/15727878).
- Paluchowska, M. H.; Bugno, R.; Bojarski, A. J.; Charakchieva-Minol, S.; Duszyńska, B.; Tatarczyńska, E.; Kłodzinska, A.; Stachowicz, K.; Chojnacka-Wójcik, E. Novel, flexible, and conformationally defined analogs of gepirone: synthesis and 5-HT1A, 5-HT2A, and D2 receptor activity. Bioorg. Med. Chem. 2005, 13, 1195-1200 (http://www.ncbi.nlm.nih.gov/pubmed/15670928).
- Paluchowska, M. H.; Charakchieva-Minol, S.; Tatarczynska, E.; Klodzinska, A.; Stachowicz, K.; Chojnacka-Wojcik, E. New 4-[ω-(diarylmethylamino)alkyl]- and 4-[ω-(diarylmethoxy)alkyl]-1-arylpiperazines as selective 5-HT1A/5-HT2A receptor ligands with differentiated in vivo activity. Pol. J. Pharmacol. 2004, 56, 743-754 (http://www.ncbi.nlm.nih.gov/pubmed/15662087).
- Bugno, R.; Charakchieva-Minol, S.; Paluchowska, M. H. Arylpiperazine 2-pyrrolidinone derivatives as 5-HT1A receptor ligands. Annals of the Polish Chemical Society 2003, 2, 260-264.
- Paluchowska, M. H.; Mokrosz, M. J. ; Duszyńska, B.; Kozioł, A.; Wesołowska, A.; Chojnacka-Wójcik, E. Novel 4-alkyl-1-arylpiperazines and 1,2,3,4-tetrahydroisoquinolines containing diphenylmethylamino or diphenylmethoxy fragment with differentiated 5-HT1A/5-HT2A/D2 receptor activity. Pol. J. Pharmacol. 2003, 55, 543-552 (http://www.ncbi.nlm.nih.gov/pubmed/14581712).
- Karolak-Wojciechowska, J.; Fruzinski, A.; Czylkowski, R.; Paluchowska, M. H.; Mokrosz, M. J. Spacer conformation in biologically active molecules. Part 2. Structure and conformation of 4-[2-(diphenylmethylamino)ethyl]-1-(2-methoxyphenyl) piperazine and its diphenylmethoxyanalog – potential 5-HT1A receptor ligands. J. Mol. Struc. 2003, 657, 7-17.
- Wesołowska, A.; Paluchowska, M. H.; Gołembiowska, K.; Chojnacka-Wójcik, E. Pharmacological characterization of MP349, a novel 5-HT1A-receptor antagonist with anxiolytic-like activity, in mice and rats. J. Pharm. Pharmacol. 2003, 55, 533-543 (http://www.ncbi.nlm.nih.gov/pubmed/12803776).
- Wesolowska, A.; Paluchowska, M.; Chojnacka-Wojcik, E. Involvement of presynaptic 5-HT(1A) and benzodiazepine receptors in the anticonflict activity of 5-HT(1A) receptor antagonists. Eur. J. Pharmacol. 2003, 471, 27-34 (http://www.ncbi.nlm.nih.gov/pubmed/12809949).
- Paluchowska, M. H.; Bojarski, A. J.; Bugno, R.; Charakchieva-Minol, S.; Wesołowska, A. Modification of the Structure of 4, 6-Disubstituted 2-(4-Alkyl-1-piperazinyl)pyridines: Synthesis and Their 5-HT2A Receptor Activity. Arch. Pharm. (Weinheim) 2003, 336, 104-110 (http://www.ncbi.nlm.nih.gov/pubmed/12761763).
- Wesołowska, A.; Borycz, J.; Paluchowska, M. H.; Chojnacka-Wójcik, E. Pharmacological analysis of the hypothermic effects of NAN-190 and its analogs, postsynaptic 5-HT1A receptor antagonists, in mice. Pol. J. Pharmacol. 2002, 54, 391-399 (http://www.ncbi.nlm.nih.gov/pubmed/12523493).
- Paluchowska, M. H.; Bugno, R.; Charakchieva-Minol, S.; Wesolowska, A.; Chojnacka-Wojcik, E. Novel N-[omega-[4-(2-methoxyphenyl)piperazin-1-yl]-ethyl]pyrid-2(1H)-ones with diversified 5-HT1A receptor activity. Pol. J. Pharmacol. 2002, 54, 641-646 (http://www.ncbi.nlm.nih.gov/pubmed/12866719)
- Karolak-Wojciechowska, J.; Fruzinski, A.; Paluchowska, M. H.; Mokrosz, M. J. Crystal structure of trans-1-(2-methoxyphenyl)-4-[4-(2-phthalimido)cyclohexyl]-piperazine chloride monohydrate, (C25H30N3O3) ClxH2O. Z. Kristallogr. NCS 2002, 217, 437-438
- Paluchowska, M. H.; Bojarski, A. J.; Charakchieva-Minol, S.; Wesołowska, A. Active Conformation of Some Arylpiperazine Postsynaptic 5-HT1A Receptor Antagonists. Eur. J. Med. Chem. 2002, 37, 273-283 (http://www.ncbi.nlm.nih.gov/pubmed/15727878)
- Paluchowska, M. H.; Bugno, R.; Charakchieva-Minol, S.; Bojarski, A. J.; Wesołowska, A. Substitution mode of the amide fragment in some new N-{ω-[4-(2-methoxyphenyl)piperazin-1-yl]alkyl}pyrid-2(1H)-ones and their 5-HT1A/5-HT2A activity. Pol. J. Pharmacol. 2001, 53, 369-376 (http://www.ncbi.nlm.nih.gov/pubmed/11990083).
- Paluchowska, M. H.; Duszyńska, B.; Kłodzińska, A.; Tatarczyńska, E. Influence of the aliphatic spacer length on the 5-HT1A receptor activity of new arylpiperazines with an indazole system. Pol. J. Pharmacol. 2000, 52, 209-216 (http://www.ncbi.nlm.nih.gov/pubmed/11055578)
- Chojnacka-Wójcik, E.; Kłodzińska, A.; Tatarczyńska, E.; Paluchowska, M. H. Some pharmacological properties of new analogs of MP 3022, the 5-HT1A receptor antagonist. Pol. J. Pharmacol. 1999, 51, 405-413 (http://www.ncbi.nlm.nih.gov/pubmed/10817541).
- Paluchowska, M. H.; Mokrosz, M. J. ; Bojarski, A. J.; Wesołowska, A.; Borycz, J.; Charakchieva-Minol, S.; Chojnacka-Wójcik, E. On the bioactive conformation of NAN-190 (1) and MP3022 (2), 5-HT(1A) receptor antagonists. J. Med. Chem. 1999, 42, 4952-4960 (http://www.ncbi.nlm.nih.gov/pubmed/10585205).
- Paluchowska, M. H.; Charakchieva-Minol, S.; Tatarczyńska, E.; Kłodzińska, A. Effect of the amide fragment on 5-HT1A receptor activity of some analogs of MP 3022 . Pol. J. Pharmacol. 1999, 51, 415-421 (http://www.ncbi.nlm.nih.gov/pubmed/10817542)
- Paluchowska, M. H.; Kłodzińska, A.; Tatarczyńska, E.; Szaro, A.; Chojnacka-Wójcik, E. Effect of linking bridge modifications on the 5-HT1A receptor activity of some 4-(ω-benzotriazol-1-yl)alkyl-1-(2-methoxyphenyl) piperazines. Pol. J. Pharmacol. 1998, 50, 341-347 (http://www.ncbi.nlm.nih.gov/pubmed/10091719).
- Karolak-Wojciechowska, J.; Fruzinski, A.; Bojarski, A. J.; Paluchowska, M. H.; Mokrosz, M. J. Structureactivity relationship studies of CNS agents. Part 33. Crystal and molecular structure of 4-[ω-(benzotriazolyl) alkyl-1-(2-methoxyphenyl)piperazines with a different pharmacological activity. Arch. Pharm. (Weinheim) 1998, 331, 299-307 (http://onlinelibrary.wiley.com/doi/10.1002/(SICI)1521-4184(199810)331:10%3C299::AID-ARDP299%3E3.0.CO;2-3/abstract).
- Misztal, S.; Paluchowska, M. H. Receptory serotoninowe typu 5-HT3. Wiad. Chem. 1997, 51, 623-641.
- Mokrosz, M. J.; Paluchowska, M. H. ; Charakchieva-Minol, S.; Bien, A. Structure-activity relationship studies of CNS agents, Part 32: Effect of structural modifications in 1-arylpiperazine derivatives on alpha(1)-adrenoreceptor affinity. Arch. Pharm. (Weinheim) 1997, 330, 177-180 (http://www.ncbi.nlm.nih.gov/pubmed/9264242)
- Paluchowska, M. H.; Dereń-Wesołek, A.; Mokrosz, J. L.; Charakchieva-Minol, S.; Chojnacka-Wójcik, E. Analogs of MP 3022 with a Different Number of Nitrogen Atoms in the Heteroaromatic Fragment – New 5-HT1A Receptor Ligands . Arch. Pharm. (Weinheim) 1996, 32, 451-456 (http://www.ncbi.nlm.nih.gov/pubmed/8933747).
- Paluchowska, M. H.; Dereń-Wesołek, A.; Charakchieva-Minol, S.; Chojnacka-Wójcik, E.; Mokrosz, J. L. Structure-Activity Relationship Studies of CNS Agents. Part 27. 1-(2-Methoxyphenyl)-4-n-propylpiperazines Containing a Substituted Benzotriazole Ring System: New Ligands with Varied Function at 5-HT1A Receptors. Med. Chem. Res. 1995, 5, 479-486.
- Mokrosz, J. L.; Paluchowska, M. H. ; Kłodzińska, A.; Charakchieva-Minol, S.; Chojnacka-Wójcik, E. Structure-Activity Relationship Studies of CNS Agents. Part 26. 4-[2-(Cycloalkanecarboxamido)ethyl]-1-(2-methoxyphenyl)piperazines: High-Affinity 5-HT1A Agonists. Arch. Pharm. (Weinheim) 1995, 328, 770-774 (http://onlinelibrary.wiley.com/doi/10.1002/ardp.19953281108/abstract).
- Mokrosz, J. L.; Duszyńska, B.; Paluchowska, M. H.; Charakchieva-Minol, S.; Mokrosz, M. J. Structure-Activity Relationship Studies of CNS Agents. Part 22. A Search for New Trazodone-Like Antidepressants: Synthesis and Preliminary Receptor Binding Studies. Arch. Pharm. (Weinheim) 1995, 328, 623-625 (http://www.ncbi.nlm.nih.gov/pubmed/7492269).
- Bojarski, A. J.; Mokrosz, M. J.; Paluchowska, M. H. Ionization Constants of the Model N-Alkyl Substituted Cyclic Amines. Pharmazie 1995, 50, 569-570
- Mokrosz, J. L.; Mokrosz, M. J.; Charakchieva-Minol, S.; Paluchowska, M. H.; Bojarski, A. J.; Duszyńska, B. Structure-Activity Relationship Studies of CNS Agents, XIX: Quantitative Analysis of the Alkyl Chain Effects on the 5-HT1A and 5-HT2 Receptor Affinities of 4-Alkyl-1-arylpiperazines and their Analogs. Arch. Pharm. (Weinheim) 1995, 328, 143-148 (http://www.ncbi.nlm.nih.gov/pubmed/7726740).
- Mokrosz, M. J.; Paluchowska, M. H. ; Misztal, S. Mild Oxidation of 1,2,3,4-Tetrahydro-β-carbolines. Pol. J. Chem. 1995, 69, 264-268
- Bartoń, H. J.; Paluchowska, M. H.; Bojarski, J.; Rys, B. On the Structure of some Substituted 4,6-Pyrimidinediones. Pol. J. Chem. 1995, 69, 235-245