Ryszard Bugno

Ryszard Bugno, PhD

e-mail: bugno@if-pan.krakow.pl
phone: +4812 66 23 320

 

 

 Research interests:

 

Scientific career:

 

Publications:

  1. Badarau, E.; Bugno, R.; Suzenet, F.; Bojarski, A. J.; Finaru, A. L.; Guillaumet, G. SAR studies on new bis-aryls 5-HT7 ligands: Synthesis and molecular modeling. Bioorg. Med. Chem. 2010, 18, 1958-1967 (http://www.ncbi.nlm.nih.gov/pubmed/20138771).
  2. Paluchowska, M. H.; Bugno, R.; Duszynska, B.; Tatarczynska, E.; Nikiforuk, A.; Lenda, T.; Chojnacka-Wojcik, E. The influence of modifications in imide fragment structure on 5-HT(1A) and 5-HT(7) receptor affinity and in vivo pharmacological properties of some new 1-(m-trifluoromethylphenyl)piperazines. Bioorg. Med. Chem. 2007, 15, 7116-7125 (http://www.ncbi.nlm.nih.gov/pubmed/17825569).
  3. Paluchowska, M. H.; Bugno, R.; Charakchieva-Minol, S.; Bojarski, A. J.; Tatarczynska, E.; Chojnacka-Wojcik, E. Conformational Restriction in Novel NAN-190 and MP3022 Analogs and Their 5-HT(1A) Receptor Activity. Arch. Pharm. (Weinheim) 2006, 339, 498-506 (http://www.ncbi.nlm.nih.gov/pubmed/16941730).
  4. Bojarski, A. J.; Paluchowska, M. H.; Duszynska, B.; Bugno, R.; Klodzinska, A.; Tatarczynska, E.; Chojnacka-Wojcik, E. Structure-intrinsic activity relationship studies in the group of 1-imido/amido substituted 4-(4-arylpiperazin-1-yl)cyclohexane derivatives; new, potent 5-HT(1A) receptor agents with anxiolytic- like activity. Bioorg. Med. Chem. 2006, 14, 1391-1402 (http://www.ncbi.nlm.nih.gov/pubmed/16266808).
  5. Paluchowska, M. H.; Bugno, R.; Bojarski, A. J.; Charakchieva-Minol, S.; Duszyńska, B.; Tatarczyńska, E.; Kłodzinska, A.; Stachowicz, K.; Chojnacka-Wójcik, E. Novel, flexible, and conformationally defined analogs of gepirone: synthesis and 5-HT1A, 5-HT2A, and D2 receptor activity. Bioorg. Med. Chem. 2005, 13, 1195-1200 (http://www.ncbi.nlm.nih.gov/pubmed/15670928).
  6. Kossakowski, J.; Raszkiewicz, A.; Bugno, R.; Bojarski, A. J. Introduction of a new complex imide system into the structure of LCAPs. The synthesis and a 5-HT1A, 5-HT2A and D2 receptor binding study. Pol. J. Pharmacol. 2004, 56, 843-848 (http://www.ncbi.nlm.nih.gov/pubmed/15662099).
  7. Zajdel, P.; Bojarski, A. J.; Bugno, R.; Jurczyk, S.; Kołaczkowski, M.; Nowak, M.; Subra, G.; Martinez, J.; Pawłowski, M. A study on application of impregnated synthetic peptide TLC stationary phases for the screening of 5-HT1A ligands. Part 2. Biomed. Chromatogr. 2004, 18, 542-549 (http://www.ncbi.nlm.nih.gov/pubmed/15386518).
  8. Bojarski, A. J.; Mokrosz, M. J.; Duszyńska, B.; Kozioł, A.; Bugno, R. New Imide 5-HT1A Receptor Ligands Modification of Terminal Fragment Geometry. Molecules 2004, 3, 170-177 (http://www.ncbi.nlm.nih.gov/pubmed/18007421).
  9. Bugno, R.; Charakchieva-Minol, S.; Paluchowska, M. H. Arylpiperazine 2-pyrrolidinone derivatives as 5-HT1A receptor ligands. Annals of the Polish Chemical Society 2003, 2, 260-264.
  10. Boksa, J.; Charakchieva-Minol, S.; Duszynska, B.; Bugno, R.; Klodzinska, A.; Tatarczynska, E.; Chojnacka-Wojcik, E.; Bojarski, A. J. Synthesis, in vitro and in vivo 5-HT1A/5-HT2A serotonin receptor activity of new hybrid 1,2,3,4-tetrahydro-γ-carbolines with 1-(2-methoxyphenyl)piperazine moiety. Pol. J. Pharmacol. 2003, 55, 1013-1019 (http://www.ncbi.nlm.nih.gov/pubmed/14730096).
  11. Paluchowska, M. H.; Bojarski, A. J.; Bugno, R.; Charakchieva-Minol, S.; Wesołowska, A. Modification of the Structure of 4, 6-Disubstituted 2-(4-Alkyl-1-piperazinyl)pyridines: Synthesis and Their 5-HT2A Receptor Activity. Arch. Pharm. (Weinheim) 2003, 336, 104-110 (http://www.ncbi.nlm.nih.gov/pubmed/12761763)
  12. Paluchowska, M. H.; Bugno, R.; Charakchieva-Minol, S.; Wesolowska, A.; Chojnacka-Wojcik, E. Novel N-[omega-[4-(2-methoxyphenyl)piperazin-1-yl]-ethyl]pyrid-2(1H)-ones with diversified 5-HT1A receptor activity. Pol. J. Pharmacol. 2002, 54, 641-646 (http://www.ncbi.nlm.nih.gov/pubmed/12866719).
  13. Paluchowska, M. H.; Bugno, R.; Charakchieva-Minol, S.; Bojarski, A. J.; Wesołowska, A. Substitution mode of the amide fragment in some new N-{ω-[4-(2-methoxyphenyl)piperazin-1-yl]alkyl}pyrid-2(1H)-ones and their 5-HT1A/5-HT2A activity. Pol. J. Pharmacol. 2001, 53, 369-376 (http://www.ncbi.nlm.nih.gov/pubmed/11990083).

 

Participation in research projects:

  • EXtention of academia-based PLATFORM to antidepressant hits discovery (PLATFORMex), Pol-Nor/198887/73/2013, function: executor, 2013 –
  • Innovative therapies for neurodegenerative and neurodevelopmental diseases based on mGlu receptor allosteric modulators – Allosterix, NCBiR 178469, function: executor, 2013 –
  • Demeter – Depression – mechanisms – therapy, WND-POIG.01.01.02-12.004/09 (http://www.de-me-ter.pl), function: executor, 2010-2014.
  • Allosteric modulation – new strategy in pharmacotherapy. Identification of the psychotropic properties of glutamatergic receptor ligands of group III. WND-POIG.01.03.01-12-100/08 (http://modall.pl), function: executor, 2011-2012.
  • Creating an academia-based platform to discover substances acting on serotonergic or glutamatergic systems as potential new antidepressant or anxiolytic drugs. PNRF-103-AI-1/07 (http://cns-platform.eu/main.html), function: executor, 2010-2011.
  • Antagonists of 5-HT6 receptor as advanced antipsychotic drugs with procognitive properties, UDA-POIG.01.03.01-12-063/09-02 (http://www.prokog.pl), function: executor, 2010-2013.

Scientific reports:

a) posters:

  1. Brański, P.; Stankiewicz, A.; Bojarski, A.; Burnat, G.; Chorobik, P.; Chruścicka, B.; Bugno, R.; Pałucha-Poniewiara, A.; Pilc, A.; IF270750: Synthesis and pharmacology of novel mGluR4 positive allosteric modulator;  The Twenty First Days of Neuropsychopharmacology, 10-13.06.2012, Ustroń-Jaszowiec, Poland, Pharmacological Reports, 2012, 64, p.470.
  2. Stankiewicz, A.; Bugno, R.; Brański, P.; Bojarski, A.J.; Design and synthesis of novel metabotropic glutamate receptor allosteric modulators; The Twenty First Days of Neuropsychopharmacology, 10-13.06.2012, Ustroń-Jaszowiec, Poland, Pharmacological Reports, 2012, 64, p.473. Abstract
  3. Brański, P.; Staroń, J.; Bugno, R.; Wierońska, J.; Bojarski, A.J.; Burnat, G.; Pałucha-Poniewiara, A.; Pilc, A.; Synthesis and characterization of novel metabotropic glutamate receptor 2/3 (mGluR2/3) positive allosteric modulator (PAM); The Twentieth Days of Neuropsychopharmacology, 22-25.05.2011, Ustroń-Jaszowiec,Poland, Pharmacological Reports, 2011, 63, p.577.
  4. Bugno, R.; Duszyńska, B.; Satała, G.; Mordalski, S.; Chmielarz, P.; Nalepa, I.; Bojarski, A.J.; Searching of novel leads for 5-HT7 receptor antagonists – selectivity hints from molecular modeling studies; VII Joint Meeting on Medicinal Chemistry, 26-27.06.2011, Catania, Italy, Book of Abstracts, p.189. Abstract Poster
  5. Trela, M.; Bugno, R.; Kurczab, R.; Brański, P.; Bojarski, A.J.; New heterocyclic derivatives as potential allosteric modulators of group III metabotropic glutamate receptors; 4th International Symposium on Advances in Synthetic and Medicinal Chemistry, 21-25.08.2011, St. Petersburg, Russia, Book of Abstracts, p.220. Abstract Poster
  6. Staroń, J.; Warszycki, D.; Satała, G.; Bugno, R.; Bojarski, A.J.; Bioisosterism, the use in designing 5-HT6 receptor ligands; 4th International Symposium on Advances in Synthetic and Medicinal Chemistry, 21-25.08.2011, St. Petersburg, Russia, Book of Abstracts, p.176. Abstract Poster
  7. Stankiewicz, A.; Bugno, R.; Brański, P.; Bojarski, A.J.; 1,2,4-Oxadiazole derivatives as potential allosteric modulators of the mglur4; 4th International Symposium on Advances in Synthetic and Medicinal Chemistry, 21-25.08.2011, St. Petersburg, Russia, Book of Abstracts.
  8. Brański, P.; Staroń, J.; Bugno, R.; Wierońska, J.; Bojarski, A.; Burnat, G.; Chorobik, P.; Chruścicka, B.; Pałucha-Poniewiara, A.; Sławińska, A.; Stachowicz, K.; Pilc, A.; Discovery of novel and systemically active allosteric ligand of metabotropic glutamate receptor group II with potential anxiolytic properties; 4th International Symposium on Advances in Synthetic and Medicinal Chemistry, 21-25.08.2011, St. Petersburg, Russia, Book of Abstracts.
  9. Brański, P.; Bojarski, A.; Burnat, G.; Chorobik, P.; Bugno, R.; Kurczab, R.; Staroń, J.; Chruścicka, B.; Pałucha-Poniewiara, A.; Pilc, A.; Searching for a new potential mGluR4 positive allosteric modulators; 7th International Meeting on Metabotropic Glutamate Receptors, 02-07.10.2011 Taormina, Italy, Curr. Neuropharmacol., 2011, 9, Suppl. 1.
  10. Bugno, R.; Satała, G.; Duszyńska, B.; Kurczab, R.; Bojarski, A.J.; Examination of 5-HT6 receptor affinity in the group of arylsulfonamide derivatives; The Seventh Multidisciplinary Conference on Drug Research, 09-12.05.2010, Zakopane, Poland, Book of Abstracts, p.25. Abstract Poster
  11. Satała, G.; Bugno, R.; Duszyńska, B.; Kurczab, R.; Bojarski, A.J.; Verification of Virtual Screening Results for 5-HT6 Receptor in In Vitro Experiments; 3rd Conversatory on Medicinal Chemistry, 20-22.09.2010, Lublin, Poland, Book of Abstracts, p.PP-12. Abstract Poster
  12. Bugno, R.; Kozioł, A.; Nędza, K.; Bojarski, A.; The research of the key-structure fragments of arylpiperazine and arylsulfonamide derivatives influences on selectivity. Towards 5-HT 7 vs  5-HT1A; 2nd Conversatory on Medicinal Chemistry, 08-10.09.2009, Lublin, Poland, Book of Astracts, p.PK-8. Abstract
  13. Staroń, J.; Bugno, R.; Brański, P.; Azo dyes as potential allosteric modulators of the metabotropic glutamate receptors mGluR4; 2nd Conversatory on Medicinal Chemistry, 08-10.09.2009, Lublin, Poland, Book of Astracts, p.P-44. Abstract Poster
  14. Trela, M.; Bugno, R.; New derivatives of indole – analogues of MMPIP – an allosteric modulator of the metabotropic glutamatergic receptors mGluR7; 2nd Conversatory on Medicinal Chemistry, 08-10.09.2009, Lublin, Poland, Book of Astracts, p.P-50. Abstract Poster