Rafał Kurczab, PhD

Rafał Kurczab , PhD

e-mail: kurczab@if-pan.krakow.pl
phone: +4812 66 23 301
ORCID: 0000-0002-9555-3905
ResearchGate
Google Scholar

Research interests:

  • computer-aided drug design
  • pharmacophore modeling
  • virtual screening
  • machine learning
  • homology modelling
  • GPCR
  • in silico polypharmacology

Scientific career:

  • MSc obtained in 2008 (Jagiellonian University Faculty of Chemistry),
  • Ph.D. obtained in 2013 (Jagiellonian University Faculty of Chemistry).
  • Habilitation obtained in 2019 (Jagiellonian University Medical College Faculty of Pharmacy).

Publications:

2023

1. Grychowska, K., López-Sánchez, U., Vitalis, M., Canet, G., Satała, G., Olejarz-Maciej, A., Gołębiowska, J., Kurczab, R., Pietruś, W., Kubacka, M., Moreau, C., Walczak, M., Blicharz-Futera, K., Bantreil, X., Subra, G., Bojarski, A., Lamaty, F., Bécamel, C., Zussy, C., Chaumont-Dubel, S., Popik, P., Nury, H., Marin, P., Givalois, L., Zajdel, P., Superiority of the triple-acting 5-HT6R/5-HT3R antagonist and MAO-B reversible inhibitor PZ-1922 over 5-HT6R antagonist intepirdine in alleviation of cognitive deficits in rats, J. Med. Chem., 2023, accepted.

2. Czarnota-Łydka, K., Sudoł-Tałaj, S., Kucwaj-Brysz, K., Kurczab, R., Satała, G., de Candia, M., Samarelli, F., Altomare, C. D., Carocci, A., Barbarossa, A., Żesławska, E., Głuch-Lutwin, M., Mordyl, B., Kubacka, M., Wilczyńska-Zawal, N., Jastrzębska-Więsek, M., Partyka, A., Khan, N., Więcek, M., Handzlik, J. Synthesis, computational and experimental pharmacological studies for (thio)ether-triazine 5-HT6R ligands with noticeable action on AChE/BChE and chalcogen-dependent intrinsic activity in search for new class of drugs against Alzheimer’s disease. Eur. J. Med. Chem., 2023, 259, 115695.

3. Sudoł-Tałaj, S., Kucwaj-Brysz, K., Podlewska, S., Kurczab, R., Satała, G., Mordyl, B., Głuch-Lutwin, M., Wilczyńska-Zawal, N., Jastrzębska-Więsek, M., Czarnota-Łydka, K., Kurowska, K., Kubacka, M., Żesławska, E., Nitek, W., Olejarz-Maciej, A., Doroz-Płonka, A., Partyka, A., Latacz, G., Wesołowska, A., Handzlik, J. Hydrophobicity modulation via the substituents at positions 2 and 4 of 1,3,5-triazine to enhance therapeutic ability against Alzheimer’s disease for potent serotonin 5-HT6R agents. Eur. J. Med. Chem. 2023, 260, 115756.

4. Zagórska, A., Partyka, A., Jastrzębska-Więsek, M., Czopek, A., Fryc, M., Siwek, A., Głuch-Lutwin, M., Mordyl, B., Maślanka, A., Jaromin, A., Kurczab, R. Synthesis, computational simulations and biological evaluation of new dual 5HT1A/5HT7 receptor ligands based on purine-2,6-dione scaffold.Bioorg Chem., 2023, 139, 106737.

5. Grychowska, K., Pietruś, W., Kulawik, L., Bento, O., Satała, G., Bantreil, X., Lamaty, F., Bojarski, A. J., Gołębiowska, J., Nikiforuk, A., Marin, P., Chaumont-Dubel, S., Kurczab, R., & Zajdel, P. Impact of the Substitution Pattern at the Basic Center and Geometry of the Amine Fragment on 5-HT6 and D3R Affinity in the 1H-Pyrrolo[3,2-c]quinoline Series. Molecules, 2023, 28(3), 1096.

6. Pietruś, W., Stypik, M., Zagozda, M., Banach, M., Gurba-Bryśkiewicz, L., Maruszak, W., Leniak, A., Kurczab, R., Ochal, Z., Dubiel, K., & Wieczorek, M. Tuning the Biological Activity of PI3Kδ Inhibitor by the Introduction of a Fluorine Atom Using the Computational Workflow. Molecules, 2023, 28(8), 3531

7. Pietruś, W., Kurczab, R., Warszycki, D., Bojarski, A. J., & Bajorath, J. Isomeric Activity Cliffs—A Case Study for Fluorine Substitution of Aminergic G Protein-Coupled Receptor Ligands. Molecules, 2023, 28(2), 490.

2022

8. Papierska, K.; Krajka-Kuźniak, V.; Kleszcz, R.; Stefański, T.; Kurczab, R.; Kubicki, M. The synthesis of novel thioderivative chalcones and their influence on NF-κB, STAT3 and Nrf2 signaling pathways in colorectal cancer cells. Sci. Rep. 2022, 12 (1), 1-17,

9. Świądro-Piętoń, M.; Morawiec, K.A.; Wójtowicz, A.; Świądro, S.; Kurczab, R.; Dudek, D.; Wietecha-Posłuszny, R.; Fast and Noninvasive Hair Test for Preliminary Diagnosis of Mood Disorders. Molecules 2022, 27 (16), 5318,

10. Wołczyk, M.; Proszewska, M.; Maziarka, Ł.; Zieba, M.; Wielopolski, P.; Kurczab, R.; Smieja, M.; PluGeN: Multi-Label Conditional Generation From Pre-Trained Models Proceedings of the AAAI Conference on Artificial Intelligence 2022, 36 (8), 8647-8656,

11. Kuzniak-Glanowska, E.; Glanowski, M.; Kurczab, R.; Bojarski, A. J.; Podgajny, R. Mining Anion–Aromatic Interactions in the Protein Data Bank. Chem. Sci. 2022, 13 (14), 3984–3998,

12. Grychowska, K.; Olejarz-Maciej, A.; Blicharz, K.; Pietruś, W.; Karcz, T.; Kurczab, R.; Koczurkiewicz, P.; Doroz-Płonka, A.; Latacz, G.; Keeri, A. R.; Piska, K.; Satała, G.; Pęgiel, J.; Trybała, W.; Jastrzębska-Więsek, M.; Bojarski, A. J.; Lamaty, F.; Partyka, A.; Walczak, M.; Krawczyk, M.; Malikowska-Racia, N.; Popik, P.; Zajdel, P. Overcoming Undesirable HERG Affinity by Incorporating Fluorine Atoms: A Case of MAO-B Inhibitors Derived from 1 H-Pyrrolo-[3,2-c]Quinolines. Eur. J. Med. Chem. 2022, 236, 114329,

13. Kucwaj-Brysz, K., Ali, W., Kurczab, R., Sudoł-Tałaj, S., Wilczyńska-Zawal, N., Jastrzębska-Więsek, M., et al. An exit beyond the pharmacophore model for 5-HT6R agents – a new strategy to gain dual 5-HT6/5-HT2A action for triazine derivatives with procognitive potential. Bioorg Chem., 2022, 121, 105695,

14. Pietruś, W. P.; Kafel, R.; Bojarski, A. J.; Kurczab, R. Hydrogen Bonds with Fluorine in Ligand-Protein Complexes-the PDB Analysis and Energy Calculations. Molecules, 2022, 27, 1005,

2021

15. Vanda, D., Canale, V., Chaumont-Dubel, S., Kurczab, R., Satała, G., Koczurkiewicz-Adamczyk, P., Krawczyk, M., Pietruś, W., Blicharz, K., Pękala, E., Bojarski, A. J., Popik, P., Marin, P., Soural, M., Zajdel, P. Imidazopyridine-Based 5-HT6 Receptor Neutral Antagonists: Impact of N 1-Benzyl and N 1 -Phenylsulfonyl Fragments on Different Receptor Conformational States. J. Med. Chem., 2021, 64(2), 1180–1196.

16. Podlewska, S., Kurczab, R. Mutual Support of Ligand- and Structure-Based Approaches—To What Extent We Can Optimize the Power of Predictive Model? Case Study of Opioid Receptors. Molecules, 2021, 26(6), 1607.

17. Drop, M., Canale, V., Chaumont-Dubel, S., Kurczab, R., Satała, G., Bantreil, X., Walczak, M., Koczurkiewicz-Adamczyk, P., Latacz, G., Gwizdak, A., Krawczyk, M., Gołębiowska, J., Grychowska, K., Bojarski, A. J., Nikiforuk, A., Subra, G., Martinez, J., Pawłowski, M., Popik, P., Zajdel, P. 2-Phenyl-1H -pyrrole-3-carboxamide as a New Scaffold for Developing 5-HT6 Receptor Inverse Agonists with Cognition-Enhancing Activity. ACS Chem. Neurosci., 2021, 12(7), 1228–1240.

18. Pietruś, W., Kurczab, R., Kafel, R., Machalska, E., Kalinowska-Tłuścik, J., Hogendorf, A., Żylewski, M., Baranska, M., & Bojarski, A. J. How can fluorine directly and indirectly affect the hydrogen bonding in molecular systems? – A case study for monofluoroanilines. Spec. Acta Part A: Molecular and Biomolecular Spectroscopy, 2021, 252, 119536.

19. Staroń, J., Pietruś, W., Bugno, R., Kurczab, R., Satała, G., Warszycki, D., Lenda, T., Wantuch, A., Hogendorf, A. S., Hogendorf, A., Duszyńska, B., & Bojarski, A. J. Tuning the activity of known drugs via the introduction of halogen atoms, a case study of SERT ligands – Fluoxetine and fluvoxamine. Eur. J. Med. Chem., 2021, 220, 113533.

20. Hogendorf, A., Hogendorf, A. S., Kurczab, R., Satała, G., Szewczyk, B., Cieślik, P., Latacz, G., Handzlik, J., Lenda, T., Kaczorowska, K., Staroń, J., Bugno, R., Duszyńska, B., Bojarski, A. J. N-Skatyltryptamines—Dual 5-HT6R/D2R Ligands with Antipsychotic and Procognitive Potential. Molecules, 2021, 26(15), 4605.

21. Wójtowicz, A., Mitura, A., Wietecha-Posłuszny, R., Kurczab, R., Zawadzki, M. Spectroscopy as a useful tool for the identification of changes with time in post-mortem vitreous humor for forensic toxicology purposes. Monatshefte Für Chemie – Chemical Monthly, 2021, 152(7), 745–755.

22. Pietruś, W., Kurczab, R., Kalinowska‐Tłuścik, J., Machalska, E., Golonka, D., Barańska, M., Bojarski, A. J. Influence of Fluorine Substitution on Nonbonding Interactions in Selected Para‐Halogeno Anilines. ChemPhysChem, 2021, 22(20), 2115–2127.

23. Warszycki, D., Struski, Ł., Śmieja, M., Kafel, R., Kurczab, R. Pharmacoprint: A Combination of a Pharmacophore Fingerprint and Artificial Intelligence as a Tool for Computer-Aided Drug Design. J. Chem. Inf. Mod., 2021, 61(10), 5054–5065.

24. Mordalski, S., Wojtuch, A., Podolak, I., Kurczab, R., Bojarski, A. J. 2D SIFt: a matrix of ligand-receptor interactions. J. Cheminformatics, 2021, 13(1), 1–8.

25. Pietruś, W., Kurczab, R., Stumpfe, D., Bojarski, A. J., Bajorath, J. Data-Driven Analysis of Fluorination of Ligands of Aminergic G Protein Coupled Receptors. Biomolecules, 2021, 11(11), 1647.

26. Zajdel, P., Grychowska, K., Mogilski, S., Kurczab, R., Satała, G., Bugno, R., Kos, T., Gołębiowska, J., Malikowska-Racia, N., Nikiforuk, A., Chaumont-Dubel, S., Bantreil, X., Pawłowski, M., Martinez, J., Subra, G., Lamaty, F., Marin, P., Bojarski, A. J., Popik, P. Structure-Based Design and Optimization of FPPQ, a Dual-Acting 5-HT3 and 5-HT6 Receptor Antagonist with Antipsychotic and Procognitive Properties. J. Med. Chem., 2021, 64(18), 13279–13298.

2020

27. Canale, V.; Grychowska, K.; Kurczab, R.; Ryng, M.; Keeri, A. R.; Satała, G.; Olejarz-Maciej, A.; Koczurkiewicz, P.; Drop, M.; Blicharz, K.; Piska, K.; Pękala, E.; Janiszewska, P.; Krawczyk, M.; Walczak, M.; Chaumont-Dubel, S.; Bojarski, A. J.; Marin, P.; Popik, P.; Zajdel, P. A dual-acting 5-HT6 receptor inverse agonist/MAO-B inhibitor displays glioprotective and pro-cognitive properties. Eur. J. Med. Chem., 2020, 208, 112765.

28. Kurek, J.; Kwaśniewska-Sip, P.; Myszkowski, K.; Pospieszny, T.; Cofta, G.; Murias, M.; Kurczab, R.; Śliwa, P. 10-Methylthiocolchicine complexes with lithium, sodium, potassium, rubidium and cesium metal cations salts – Cytotoxic, semi-empirical and molecular modelling studies. Polyhedron, 2020, 190, 114791.

29. Czaja, K.; Kujawski, J.; Śliwa, P.; Kurczab, R.; Kujawski, R.; Stodolna, A.; Myślińska, A.; Bernard, M. K. Theoretical Investigations on Interactions of Arylsulphonyl Indazole Derivatives as Potential Ligands of VEGFR2 Kinase. Int. J. Mol. Sci. 2020, 21, 4793.

30. Sudoł, S.; Kucwaj-Brysz, K.; Kurczab, R.; Wilczyńska, N.; Jastrzębska-Więsek, M.; Satała, G.; Latacz, G.; Głuch-Lutwin, M.; Mordyl, B.; Żesławska, E.; Nitek, W.; Partyka, A.; Buzun, K.; Doroz-Płonka, A.; Wesołowska, A.; Bielawska, A.; Handzlik, J. Chlorine substituents and linker topology as factors of 5-HT6R activity for novel highly active 1,3,5-triazine derivatives with procognitive properties in vivo. Eur. J. Med. Chem., 2020, 203, 112529.

31. Staroń, J.; Kurczab, R.; Warszycki, D.; Satała, G.; Krawczyk, M.; Bugno, R.; et al. Virtual screening-driven discovery of dual 5-HT6/5-HT2A receptor ligands with pro-cognitive properties. Eur. J. Med. Chem., 2020, 185, 111857.

2019

32. Kurek, J.; Kwaśniewska-Sip, P.; Myszkowski, K.; Cofta, G.; Barczyński, P.; Murias, M.; et al. Antifungal, anticancer, and docking studies of colchiceine complexes with monovalent metal cation salts. Chem. Biol. Drug. Des., 2019, 94(5), 1930–43.

33. Hogendorf, A.S.; Hogendorf, A.; Kurczab, R.; Kalinowska-Tłuścik, J.; Popik, P.; Nikiforuk, A.; et al. 2-Aminoimidazole-based antagonists of the 5-HT6 receptor – A new concept in aminergic GPCR ligand design. Eur. J. Med. Chem., 2019, 179, 1–15.

34. Grychowska, K.; Chaumont-Dubel, S.; Kurczab, R.; Koczurkiewicz, P.; Deville, C.; Krawczyk, M.; et al. Dual 5-HT6 and D3 Receptor Antagonists in a Group of 1H-Pyrrolo[3,2-c]quinolines with Neuroprotective and Procognitive Activity. ACS Chem. Neurosci., 2019, 10(7), 3183–96.

35. Śliwa, P.; Kurczab, R.; Kafel, R.; Drabczyk, A.; Jaśkowska, J.; Recognition of repulsive and attractive regions of selected serotonin receptor binding site using FMO-EDA approach. J. Mol. Model., 2019, 25(5), 114.

36. Hogendorf, A.S.; Hogendorf, A.; Popiołek-Barczyk, K.; Ciechanowska, A.; Mika, J.; Satała, G.; et al. Fluorinated indole-imidazole conjugates: Selective orally bioavailable 5-HT7 receptor low-basicity agonists, potential neuropathic painkillers. Eur. J. Med. Chem., 2019, 170, 261–75.

37. Łażewska, D.; Kurczab, R.; Więcek, M.; Satała, G.; Kieć-Kononowicz, K.; Handzlik, J. Synthesis and computer-aided analysis of the role of linker for novel ligands of the 5-HT6 serotonin receptor among substituted 1,3,5-triazinylpiperazines. Bioorg Chem, 2019, 84, 319–25.

38. Kurczab, R.; Kucwaj-Brysz, K.; Śliwa, P.; The Significance of Halogen Bonding in Ligand–Receptor Interactions: The Lesson Learned from Molecular Dynamic Simulations of the D4 Receptor, Molecules, 2019, 25(1), 91.

39. Ali, W.; Więcek, M.; Łażewska, D.; Kurczab, R.; Jastrzębska-Więsek, M.; Satała, G.; et al. Synthesis and computer-aided SAR studies for derivatives of phenoxyalkyl-1,3,5-triazine as the new potent ligands for serotonin receptors 5-HT6. Eur. J. Med. Chem., 2019, 178, 740–51.

40. Owczarzak, A.; Dutkiewicz, Z.; Kurczab, R.; Pietruś, W.; Kubicki, M.; Grześkiewicz, A.M.; Role of Staple Molecules in the Formation of S···S Contact in Thioamides: Experimental Charge Density and Theoretical Studies. Cryst Growth Des, 2019, 19(12), 7324–35.

41. Lubelska, A.; Latacz, G.; Jastrzębska-Więsek, M.; Kotańska, M.; Kurczab, R.; Partyka, A.; et al. Are the Hydantoin-1,3,5-triazine 5-HT6R Ligands a Hope to a Find New Procognitive and Anti-Obesity Drug? Considerations Based on Primary In Vivo Assays and ADME-Tox Profile In Vitro. Molecules, 2019, 24(24), 4472.

2018

42. Kurczab, R.; Śliwa, P.; Rataj, K.; Kafel, R.; Bojarski, A.J.; The salt bridge in ligand-protein complexes – systematic theoretical and statistical investigations, J. Chem. Inf. Model., 2018, 58, 2224–2238.

43. Kurczab, R.; Ali, W.; Łażewska, D.; Kotańska, M.; Jastrzębska-Więsek, M.; Satała, G.; Więcek, M.; Lubelska, A.; Latacz, G.; Partyka, A.; et al. Computer-Aided Studies for Novel Arylhydantoin 1,3,5-Triazine Derivatives as 5-HT6 Serotonin Receptor Ligands with Antidepressive-Like, Anxiolytic and Antiobesity Action In Vivo. Molecules, 2018, 23 (10), 2529.

44. Kurczab, R.; Canale, V.; Satała, G.; Zajdel, P.; Bojarski, A. J., Amino Acid Hot Spots of Halogen Bonding–a Combined Theoretical and Experimental Case Study of the 5-HT7 Receptor. J. Med. Chem. 2018, 61 (19), 8717–8733.

45. Kurek, J.; Kwaśniewska-Sip, P.; Myszkowski, K.; Cofta, G.; Murias, M.; Barczyński, P.; Jasiewicz, B.; Kurczab, R. 7-Deacetyl-10-alkylthiocolchicine derivatives – new compounds with potent anticancer and fungicidal activity, Med. Chem. Commun., 2018, 10.1039/C8MD00352A.

46. Grychowska, K.; Kurczab, R.; Śliwa, P.; Satała, G.; Dubiel, K.; Matłoka, M.; Moszczyński-Pętkowski, R.; Pieczykolan, J.; Bojarski, A. J.; Zajdel, P. Pyrroloquinoline Scaffold-Based 5-HT6R Ligands: Synthesis, Quantum Chemical and Molecular Dynamic Studies, and Influence of Nitrogen Atom Position in the Scaffold on Affinity. BioorgMed. Chem. 2018, 26 (12), 3588–3595.

47. Marciniec, K.; Kurczab, R.; Książek, M.; Bębenek, E.; Chrobak, E.; Satała, G.; Bojarski, A. J.; Kusz, J.; Zajdel, P. Structural Determinants Influencing Halogen Bonding: A Case Study on Azinesulfonamide Analogs of Aripiprazole as 5-HT1A, 5-HT7, and D2 Receptor Ligands. Cent. J. 2018, 12 (1), 55.

48. Kucwaj-Brysz, K.; Kurczab, R.; Żesławska, E.; Lubelska, A.; Marć, M. A.; Latacz, G.; Satała, G.; Nitek, W.; Kieć-Kononowicz, K.; Handzlik, J. The Role of Aryl-Topology in Balancing between Selective and Dual 5-HT7R/5-HT1A Actions of 3,5-Substituted Hydantoins. Medchemcomm 2018, 9 (6), 1033–1044,

49. Śliwa P., Kurczab R., Bojarski A. J., ONIOM and FMO-EDA study of metabotropic glutamate receptor 1 – quantum insights into the allosteric binding site, Int J Quantum Chem. 2018, e25617.

50. Kucwaj-Brysz K., Kurczab R., Jastrzębska-Więsek M., Żesławska E., Satała G., Nitek W., Partyka A., Siwek A., Jankowska A., Wesołowska A., Kieć-Kononowicz K., Handzlik J., Computer-Aided Insights into Receptor-Ligand Interaction for Novel 5-Arylhydantoin Derivatives as Serotonin 5-HT7 Receptor Agents with Antidepressant Activity. J. Med. Chem. 2018, 147, 102–114.

51. Stefański T., Mikstacka R., Kurczab R., Dutkiewicz Z., Kucińska M., Murias M., Zielińska-Przyjemska M., Cichocki M., Teubert A., Kaczmarek M., Hogendorf A., Sobiak S., Design, Synthesis, and Biological Evaluation of Novel Combretastatin A-4 Thio Derivatives as Microtubule Targeting Agents. Eur. J. Med. Chem. 2018, 144, 797–816.

2017

52. Kowalski, P.; Śliwa, P.; Satała, G.; Kurczab, R.; Bartos, I.; Zuchowicz, K. The Effect of Carboxamide/Sulfonamide Replacement in Arylpiperazinylalkyl Derivatives on Activity to Serotonin and Dopamine Receptors. Arch. Pharm. (Weinheim). 2017, e1700090.

53. Marciniec, K.; Latocha, M.; Kurczab, R.; Boryczka, S. Synthesis and Anticancer Activity Evaluation of a Quinoline-Based 1,2,3-Triazoles. Med. Chem. Res. 2017, 26, 2432–2442.

54. Partyka, A.; Kurczab, R.; Canale, V.; Satała, G.; Marciniec, K.; Pasierb, A.; Jastrzębska-Więsek, M.; Pawłowski, M.; Wesołowska, A.; Bojarski, A. J.; Zajdel, P. The Impact of the Halogen Bonding on D2 and 5-HT1A /5-HT7 Receptor Activity of Azinesulfonamides of 4-[(2-Ethyl)piperidinyl-1-Yl]phenylpiperazines with Antipsychotic and Antidepressant Properties. Bioorg. Med. Chem. 2017, 25 (14), 3638–3648

55. Hogendorf, A. S.; Hogendorf, A.; Kurczab, R.; Satała, G.; Lenda, T.; Walczak, M.; Latacz, G.; Handzlik, J.; Kieć-Kononowicz, K.; Wierońska, J. M.; Woźniak, M.; Cieślik, P.; Bugno, R.; Staroń, J.; Bojarski, A. J. Low-Basicity 5-HT7 Receptor Agonists Synthesized Using the van Leusen Multicomponent Protocol. Sci. Rep. 2017, 7 (1), 1444

56. Łażewska, D.; Kurczab, R.; Więcek, M.; Kamińska, K.; Satała, G.; Jastrzębska-Więsek, M.; Partyka, A.; Bojarski, A. J.; Wesołowska, A.; Kieć-Kononowicz, K.; Handzlik, J. The Computer-Aided Discovery of Novel Family of the 5-HT6 Serotonin Receptor Ligands among Derivatives of 4-Benzyl-1,3,5-Triazine. Eur. J. Med. Chem. 2017, 135, 117–124

57. Canale, V.; Partyka, A.; Kurczab, R.; Krawczyk, M.; Kos, T.; Satała, G.; Kubica, B.; Jastrzębska-Więsek, M.; Wesołowska, A.; Bojarski, A. J.; Popik, P.; Zajdel, P. Novel 5-HT 7 R Antagonists, Arylsulfonamide Derivatives of (Aryloxy)propyl Piperidines: Add-on Effect to the Antidepressant Activity of SSRI and DRI, and pro-Cognitive Profile. Bioorg. Med. Chem. 2017, 25 (10), 2789–2799

58. Kurczab, R.; Bojarski, A. J. The Influence of the Negative-Positive Ratio and Screening Database Size on the Performance of Machine Learning-Based Virtual Screening. PLoS One 2017, 12 (4), e0175410

59. Kurczab, R. The Evaluation of QM/MM-Driven Molecular Docking Combined with MM/GBSA Calculations as a Halogen-Bond Scoring Strategy. Acta Crystallogr. Sect. B Struct. Sci. Cryst. Eng. Mater. 2017, 73 (2), 188–194

60. Intagliata, S.; Modica, M. N.; Pittalà, V.; Salerno, L.; Siracusa, M. A.; Cagnotto, A.; Salmona, M.; Kurczab, R.; Romeo, G. New N- and O-arylpiperazinylalkyl pyrimidines and 2-methylquinazolines derivatives as 5-HT7 and 5-HT1A receptor ligands: Synthesis, structure-activity relationships, and molecular modeling studies. Bioorg. Med. Chem. 2017, 25 (3), 1250–1259.

2016

61. Canale, V.; Kurczab, R.; Partyka, A.; Satała, G.; Słoczyńska, K.; Kos, T.;Jastrzębska-Więsek, M.; Siwek, A.; Pękala, E.; Bojarski, A.J.; Wesołowska, A.; Popik, P.; Zajdel, P. N-Alkylated arylsulfonamides of (aryloxy)ethyl piperidines: 5-HT7 receptor selectivity versus multireceptor profile, Bioorg. Med. Chem. 2016, 15, S0968-0896(15)30164-4.

62. Canale, V.; Kurczab, R.; Partyka, A.; Satała, G.; Lenda, T.; Jastrzębska-Więsek, M.; Wesołowska, A.; Bojarski, A.J.; Zajdel, P. Towards new 5-HT7 antagonists among arylsulfonamide derivatives of (aryloxy)ethyl-alkyl amines: Multiobjective based design, synthesis, and antidepressant and anxiolytic properties, Eur. J. Med. Chem2016,108, 334-346.

63. Canale, V.; Kurczab, R.; Partyka, A.; Satała, G.; Lenda, T.; Jastrzębska-Więsek, M.; Wesołowska, A.; Bojarski, A.J.; Zajdel, P.  Towards new 5-HT7 antagonists among arylsulfonamide derivatives of (aryloxy)ethyl-alkyl amines: Multiobjective based design, synthesis, and antidepressant and anxiolytic properties, Eur. J. Med. Chem. 2016,108, 334-346.

64. Canale, V.; Kurczab, R.; Partyka, A.; Satała, G.; Słoczyńska, K.; Kos, T.;Jastrzębska-Więsek, M.; Siwek, A.; Pękala, E.; Bojarski, A.J.; Wesołowska, A.; Popik, P.; Zajdel, P. N-Alkylated arylsulfonamides of (aryloxy)ethyl piperidines: 5-HT7 receptor selectivity versus multireceptor profile, Bioorg. Med. Chem. 2016, 15, S0968-0896(15)30164-4.

2015

65. Canale, V.; Kurczab, R.; Partyka, A.; Satala, G.; Witek, J.; Jastrzebska-Wiesek, M.; Pawlowski, M.; Bojarski, A. J.; Wesolowska, A.; Zajdel, P. Towards novel 5-HT7 versus 5-HT1A receptor ligands among LCAPs with cyclic amino acid amide fragments: Design, synthesis, and antidepressant properties. Part II. Eur. J Med. Chem. 2015, 92, 202-211.

66. Zajdel, P.; Canale, V.; Partyka, A.; Marciniec, K.; Kurczab, R.; Satala, G. ; Siwek, A.; Jastrzebska-Wiesek, M.; Wesolowska, A.; Kos, T. ; Popik, P.; Bojarski, A. J. Arylsulfonamide derivatives of (aryloxy)ethylpiperidines as 5-HT7 receptor antagonists and their psychotropic properties. Med. Chem. Commun. 2015, 6, 2172-2177.

67. Smusz, S.; Kurczab, R.; Satała, G.; Bojarski, A. J. Fingerprint-based consensus virtual screening towards structurally new 5-HT6R ligands. Bioorg. Med. Chem. Lett. 2015, 25, 1827-1830.

2014

68. Salerno, L.; Pittalà, V.; Modica, M. N.; Siracusa, M. A.; Intagliata, S.; Cagnotto, A.; Salmona, M.; Kurczab, R.; Bojarski, A. J.; Romeo, G. Structure-activity relationships and molecular modeling studies of novel arylpiperazinylalkyl 2-benzoxazolones and 2-benzothiazolones as 5-HT7 and 5-HT1A receptor ligands. Eur J. Med. Chem. 201485, 716-726.

69. Gabrielsen, M.; Kurczab, R.; Siwek, A.; Wolak, M.; Ravna, A. W.; Kristiansen, K.; Kufareva, I.; Abagyan, R.; Nowak, G.; Chilmonczyk, Z.; Sylte, I.; Bojarski, A. J. Identification of novel serotonin transporter compounds by virtual screening. J. Chem. Inf. Model. 201454, 933-944.

70. Canale, V.; Guzik, P.; Kurczab, R.; Verdie, P.; Satala, G.; Kubica, B.; Pawlowski, M.; Martinez, J.; Subra, G.; Bojarski, A. J.; Zajdel, P. Solid-supported synthesis, molecular modeling, and biological activity of long-chain arylpiperazine derivatives with cyclic amino acid amide fragments as 5-HT and 5-HT receptor ligands. Eur. J. Med. Chem. 201478, 10-22.

71. Marciniec, K.; Latocha, M.; Boryczka, S.; Kurczab, R. Synthesis, molecular docking study, and evaluation of the antiproliferative action of a new group of propargylthio- and propargylselenoquinolines. Med. Chem. Res. 201423, 3468-3477.

72. Kurczab, R.; Smusz, S. ; Bojarski, A. J. The influence of negative training set size on machine learning-based virtual screening. J. Cheminform. 20146:32, 1-9.

2013

73. Smusz, S.; Kurczab, R.; Bojarski, A. J. A multidimensional analysis of machine learning methods performance in the classification of bioactive compounds. Chemometr. Intell. Lab. Syst. 2013128, 89-100.

74. Popieralska, H.; Myka, A.; Drabińska, B.; Gruszeczka, A.; Kruk, J.; Kurczab, R.; Kujawski, J. Pyrazole derivatives. A challenge of modern academic and industrial chemistry. Przem. Chem. 201392, 905-914.

75. Kurczab, R.; Bojarski, A. J. New Strategy for Receptor-Based Pharmacophore Query Construction: A Case Study for 5-HT7 Receptor Ligands. J. Chem. Inf. Model. 201353, 3233-3243.

76. Smusz, S.; Kurczab, R. ; Bojarski, A. J. The influence of the inactives subset generation on the performance of machine learning methods. J. Cheminform. 20135, 17.

2012

77. Gabrielsen, M.; Kurczab, R.; Ravna, A. W.; Kufareva, I.; Abagyan, R.; Chilmonczyk, Z.; Bojarski, A. J.; Sylte, I. Molecular mechanism of serotonin transporter inhibition elucidated by a new flexible docking protocol. Eur. J. Med. Chem. 201247, 24-37.

78. Zajdel, P.; Kurczab, R.; Grychowska, K.; Satała, G.; Pawłowski, M.; Bojarski, A. J. The multiobjective based design, synthesis and evaluation of the arylsulfonamide/amide derivatives of aryloxyethyl- and arylthioethyl- piperidines and pyrrolidines as a novel class of potent 5-HT7 receptor antagonists. Eur. J. Med. Chem. 201256, 348-360.

79. Marciniec, K.; Maslankiewicz, A.; Maslankiewicz, M. J.; Kurczab, R. Synthesis, 15N NMR spectra and GIAO calculated data of the seven positional isomers of 15N-labeled N,N-dimethylsulfamoylquinoline. J. Mol. Struc. 20121015, 46-50.

2010

80. Mitoraj, M. P.; Kurczab, R.; Boczar, M.; Michalak, A. Theoretical description of hydrogen bonding in oxalic acid dimer and trimer based on the combined extended-transition-state energy decomposition analysis and natural orbitals for chemical valence (ETS-NOCV). J. Mol. Model. 201016, 1789-1795.

81. Kurczab, R.; Nowak, M.; Chilmonczyk, Z.; Sylte, I.; Bojarski, A. J. The development and validation of a novel virtual screening cascade protocol to identify potential serotonin 5-HT(7)R antagonists. Bioorg. Med. Chem. Lett. 201020, 2465-2468.

82. Kurczab, R.; Mitoraj, M. P.; Michalak, A.; Ziegler, T. Theoretical analysis of the resonance assisted hydrogen bond based on the combined extended transition state method and natural orbitals for chemical valence scheme. J. Phys. Chem. A 2010114, 8581-8590.

83. Boczar, M.; Kurczab, R.; Wójcik, M. J. Theoretical and spectroscopic studies of vibrational spectra of hydrogen bonds in molecular crystal of b-oxalic acid. Vibrational Spectroscopy 201052, 39-47.

Participation in research projects:

a) as principal investigator:

  • 2019–2021 Polifarmakologiczna platforma skriningowa in silico, LIDER, LIDER/37/0137/L-9/17/NCBR/2018 supported by the Polish National Centre for Research and Development
  • 01.09.201530.10.2018 Halogen bonding – the role and significance in interactions of ligands with class A GPCRs, SONATA, UMO-2014/15/D/NZ7/01782 More
  • 01.08.2012–31.07.2013 ‚The influence of molecular fingerprint bit density on chemical pattern recognition effectiveness’, financed by the grant PRELUDIUM, No 2011/03/N/NZ2/02478
  • 2010–2013 ModAll. Allosteric modulation – new strategy in pharmacotherapy. Identification of the psychotropic roperties of glutamatergic receptor ligands of group III, co-financed by European Union from the European Fund of Regional Development (EFRD) WND-POIG.01.03.01-12-100/08, www.modall.pl, function: team leader
  • 2010–2013 Prokog. Antagonists of 5-HT6 receptor as advanced antipsychotic drugs with pro-cognitive properties, co-financed by European Union from the European Fund of Regional Development (EFRD), UDAPOIG.01.03.01-12-063/09-02, www.prokog.pl, function: team leader

b) as executor:

  • Triazynowe ligandy receptora serotoninowego 5-HT6 – nowa perspektywa w terapii współczesnych chorób cywilizacyjnych OUN, Opus UMO-2015/17/B/NZ7/02973
  • Projektowanie, synteza, badania krystalograficzne oraz ocena aktywności biologicznej nowych pochodnych chalkonów – potencjalnych czynników antymitotycznych, Opus UMO-2015/17/B/ST4/03701
  • Funkcjonalnie selektywni odwrotni agoniści receptora 5-HT6 oraz podwójne inhibitory 5-HT6/MAO-B – w poszukiwaniu nowych podejść terapeutycznych do leczenia choroby Alzheimera, Opus UMO-2016/21/B/NZ7/01742
  • from 01.11.2013 ‒ EXtention of academia-based PLATFORM to antidepressant hits discovery (PLATFORMex), Nr Pol-Nor/198887/73/2013
  • from 01.07.2013 ‒ Innovative therapies for neurodegenerative and neurodevelopmental diseases based on mGlu receptor allosteric modulators – Allosterix, NCBiR 178469, 2013-2015
  • from 01.07.2011 – Depression – Mechanisms – Therapy, co-financed by European Union from the European Fund of Regional Development (EFRD), WND-POIG.01.01.02-12-004/09-00, 2010-2013, (www.de-me-ter.pl),
  • 01.01.2010–31.06.2011 Creating an academia-based platform to discover substances acting on serotonergic or glutamatergic systems as potential new antidepressant or anxiolytic drugs. Project PNRF –103–AI-1/07, supported by a grant from Norway through the Norwegian Financial Mechanism within the Polish-Norwegian Research Fund (www.cns-platform.eu)

Scientific reports:

a) posters:

  1. Śliwa P., Jaśkowska J., Kurczab R., The application of FMO-EDA calculations to study the selectivity of 2-chlorophenylpiperazine derivative to serotonin and dopamine receptors, 10th Joint Meeting on Medicinal Chemistry, 25–29.06.2017, Dubrovnik, Chorwacja, Book of Abstracts, P-136
  2. Śliwa P., Kurczab R., Bojarski A. J., An aspartate-amine salt bridge – the ETS-NOCV study, 10th Joint Meeting on Medicinal Chemistry, 25–29.06.2017, Dubrovnik, Chorwacja, Book of Abstracts, P-137
  3. Handzlik J., Kurczab R., Łażewska D., Więcek M., Nowakowska A., Satała G., Bojarski A. J., Kieć-Kononowicz K., Search for 5-HT6 receptor agents among triazine derivatives of hydantoin, 10th Joint Meeting on Medicinal Chemistry, 25–29.06.2017, Dubrovnik, Chorwacja, Book of Abstracts, P-41
  4. Łażewska D., Więcek M., Stelmasiński M., Satała G., Kurczab R., Bojarski A. J., Kieć-Kononowicz K., Handzlik J., Phenoxymethyl derivatives of 1,3,5-triazines as novel class of 5-HT6 receptor ligands, 10th Joint Meeting on Medicinal Chemistry, 25–29.06.2017, Dubrovnik, Chorwacja, Book of Abstracts, P-79
  5. Stefański T., Kurczab R., Korzański A., Skonieczka K., Grolik B., Kania E., Bojko B., Dutkiewicz Z., Gielara-Korzańska A., Mikstacka R., Hogendorf A., Kubicki M., Design, synthesis, X-ray studies and biological evaluation of novel chalcone derivatives – potential microtubule targeting agents, 10th Joint Meeting on Medicinal Chemistry, 25–29.06.2017, Dubrovnik, Chorwacja, Book of Abstracts, P-144
  6. Kurczab R., Different roles of halogen substituents in ligand-receptor interactions – a class A GPCRs case study, 10th Joint Meeting on Medicinal Chemistry, 25–29.06.2017, Dubrovnik, Chorwacja, Book of Abstracts, P-74
  7. Pietruś W., Kurczab R., Hogendorf A., Bojarski A. J., Exploring the influence of fluorine substitution on tuning the hydrogen bonding properties using theoretical and spectroscopic methods, VIII Konwersatorium Chemii Medycznej, 15-17.09.2016, Lublin, Book of Abstracts, P-107 Abstract Poster
  8. Stefański T., Kurczab R., Dutkiewicz Z., Korzański A., Gielara-Korzańska A., Kubicki M., Design, synthesis and crystal structure of novel chalcone derivatives as potential microtubule targeting agents, VIII Konwersatorium Chemii Medycznej, 15-17.09.2016, Lublin, Book of Abstracts, P-100 Abstract
  9. Kurczab R., Śliwa P., Rataj K., Kafel R., Bojarski A. J., The salt bridge – systematic QM and database search study, VIII Konwersatorium Chemii Medycznej, 15-17.09.2016, Lublin, Book of Abstracts, P-93
  10. Śliwa P., Kurczab R., Jaśkowska J., Malinowska M., Kułaga D., Bojarski A. J., FMO/EDA study of 1-hexyl-4-(2-methoxyphenyl)piperazines as ligands of serotonin receptors, VIII Konwersatorium Chemii Medycznej, 15-17.09.2016, Lublin, Book of Abstracts, P-89 Abstract Poster
  11. Śliwa P., Kurczab R., Bojarski A. J., Assessment of quantum optimized mGlu1R in virtual screening, VIII Konwersatorium Chemii Medycznej, 15-17.09.2016, Lublin, Book of Abstracts, P-88 Abstract Poster
  12. Łażewska D., Kurczab R., Więcek M., Kamińska K., Satała G., Bojarski A. J., Kieć-Kononowicz K., Handzlik J., Methylpiperazine derivatives with 1,3,5-traizine scaffold – a novel group of ligands for serotonin receptors 5-HT6, VIII Konwersatorium Chemii Medycznej, 15-17.09.2016, Lublin, Book of Abstracts, P-50 Abstract
  13. Stankiewicz A., Kurczab R., Burnat G., Brański P., Wierońska J. M., Bojarski A. J., Pilc A., SAR determination and preliminary modelling studies for a new mGluR4 positive allosteric modulators, VIII Konwersatorium Chemii Medycznej, 15-17.09.2016, Lublin, Book of Abstracts, P-21 Abstract Poster
  14. Hogendorf A., Hogendorf A. S., Kurczab R., Satała G., Bojarski A. J., Binding mode analysis of a series of novel 5-HT1A ligands, VIII Konwersatorium Chemii Medycznej, 15-17.09.2016, Lublin, Book of Abstracts, P-4 Abstract Poster
  15. Kurczab R., Bojarski A.J. New approach for evaluation of docking results based on hybrid interaction fingerprint and machine learning methods, 11th German Conference on Chemoinformatics (GCC), 08.11–10.11.2015, Fulda, Niemcy, Book of Abstracts, P-30
  16. Kurczab R.; Bojarski, A.J. The potential role of halogen bonding in interactions of ligands with class A GPCRs – the β2 adrenergic receptor case study; VII Konwersatorium Chemii Medycznej, 17-19.09.2015, Lublin, Poland, Book of Abstracts, P-58
  17. Podlewska S., Kurczab R., Satała G., Bojarski A.J. New non-basic ligands of serotonin receptor 5-HT6 as a result of virtual screening based on machine-learning methods, VII Konwersatorium Chemii Medycznej, 17-19.09.2015, Lublin, Poland, Book of Abstracts, PP-5 Abstract Poster
  18. Canale V., Kurczab R., Satała G., Partyka A., Jastrzębska-Więsek M., Słoczyńska K., Kos T., Pękala E., Popik P., Bojarski A.J., Wesołowska A., Zajdel P., N-alkylated arylsulfonamides of (aryloxy)ethyl piperidines: 5-HT7 receptor selectivity vs multireceptor profile, VII Konwersatorium Chemii Medycznej, 17-19.09.2015, Lublin, Poland, Book of Abstracts, P-27
  19. Śliwa P., Kurczab R., Bojarski A.J, Quantum mechanical study of metabotropic glutamate receptor 1, Drug Discovery Conference, 27-29.08.2015, Riga, Latvia, Book of Abstracts, PP-59 Abstract
  20. Canale V., Partyka A., Kurczab R., Satała G., Jastrzębska-Więsek M., Wesołowska A., Kos T., Popik P., Bojarski A.J., Zajdel P. Arylsulfonamide derivatives of (aryloxy)ethyl-piperidines as 5-HT7 antagonists and their antidepressant and pro-cognitive properties, Neuronus, Ibro & Irun neuroscience forum, 17-19.04.2015, Krakow, Book of Abstracts, P-58
  21. Canale V., Kurczab R., Partyka A., Satała G., Jastrzębska-Więsek M., Wesołowska A., Bojarski A.J., Zajdel P. Arylsulfonamides of (aryloxy)ethyl derivatives of alicyclic amines as potent 5-HT7R antagonists and their psychotropic properties, European School of Medicinal Chemistry, 28.06-02.07.2015, Urbino, Book of Abstracts, P-FF Abstract
  22. Canale V., Kurczab R., Partyka A., Satała G., Jastrzębska-Więsek M., Wesołowska A., Bojarski A.J., Zajdel P. Arylsulfonamide derivatives of (aryloxy)ethyl alicyclic amines as potent 5-HT7 receptor antagonists and their psychotropic properties, V Meeting of the Paul Ehrlich MedChem Euro-Phd network, 03-05.07.2015, Krakow, Book of Abstracts, P-6/PP7 Abstract
  23. Zajdel P., Canale V., Kurczab R., Partyka A., Satała G., Bojarski A.J., Jastrzębska-Więsek M., Wesołowska A., Kos T., Popik P. LCAP biomimetic–5-HT7 receptor antagonists with antidepressant and pro-cognitive properties, Spanish-Italian Medicinal Chemistry Congress, 12-15.07.2015, Barcelona, Book of Abstracts, P-77
  24. Canale V., Partyka A., Kurczab R., Satała G., Jastrzębska-Więsek M., Wesołowska A., Kos T., Popik P., Bojarski A.J., Zajdel P. Arylosulfonamidowe pochodne (aryloksy)-etylopiperydyny jako antagoniści receptorów 5-HT7 o właściwościach przeciwdepresyjnych i prokognitywnych. V Konferencja Doktorantów Wydziału Lekarskiego i Farmaceutycznego Collegium Medicum UJ, 28-29.05.2015, Krakow, Book of Abstracts, P-30
  25. Canale V., Kurczab R., Partyka A., Satała G., Jastrzębska-Więsek M., Wesołowska A., Bojarski A.J., Zajdel P. Arylosulfonamidowe pochodne (aryloksy)-etylopiperydyny jako antagoniści receptorów 5-HT7 o właściwościach psychotropowych. II Sympozjum Szkoła Chemii Medycznej, 17-19.06.2015, Wrocław, Book of Abstracts, PP-41
  26. Kurczab R., Canale V., Zajdel P., Bojarski A.J., A step forwards to GPCRs polypharmacology: an algorithm to 5-HT7/5-HT1A selectivity prediction, GLISTEN meeting 2015 – Allschwil, 1-2.04.2015, Allschwil, Switzerland, Book of Abstracts, p. 56
  27. Stefański T., Kurczab R., Dutkiewicz Z., Mikstacka R., Cichocki M., Murias M., Gielara-Korzańska A., Sobiak S. Design, synthesis and biological evaluation of novel combretastatin A-4 derivatives – potential antimitotic agents, VI Konwersatorium Chemii Medycznej, 18-20.09.2014, Lublin, Book of Abstracts, P-22
  28. Kurczab R., Dutkiewicz Z., Stefański T., Mikstacka R., Sobiak S., Identification of novel tubulin inhibitors by parallel virtual screening protocol of reaction-based combinatorial library of combretastatin CA-4 derivatives, 10th International Conference on Chemical Structures and the 10th German Conference on Chemoinformatics (GCC), 1–5.06.2014, Noordwijkerhout, Holandia, Book of Abstracts, P-CC
  29. Stefański T., Kurczab R., Dutkiewicz Z., Cichocki M., Mikstacka R., Gierala-Korzańska A., Sobiak S., Structure-based virtual screening of novel combretastatin A-4 derivatives and experimental evaluation of their cytotoxicity and tubulin binding, 8th Joint Meeting in Medicinal Chemistry, 30.06-04.07.2013, Lublin, Book of Abstracts, P-49
  30. Kurczab, R.; Smusz, S.; Zastosowanie metod chem- i bioinformatycznych w nowoczesnym projektowaniu nowych leków; I Ogólnopolskie Sympozjum Interdyscyplinarne Inter-Mix 2013, 21-24.03.2013, Pułtusk, Poland, Book of Abstracts, p.34. Poster
  31. Kujawski, J.; Popielarska, H.; Drabińska, B.; Myka, A.; Smusz, S.; Kurczab, R.; Bojarski, A.; Synthesis and complexation abilities of new indazole derivatives with expected cytostatic activity; 15th JCF-Fruhjahrssymposium, 06-09.03.2013, Berlin, Germany, Book of Abstracts, p.238.
  32. Canale, V.; Kurczab, R.; Steczko, M.; Tytro, K.; Satała, G.; Pawłowski, M.; Bojarski, A.J.; Zajdel, P.; Synthesis of long-chain arylpiperazine derivatives with cyclic amino acid amide fragments and their biological evaluation for 5-HT7 receptors; VIIIth Joint Meeting on Medicinal Chemistry, 30.06-04.07.2013, Lublin, Poland, Book of Abstracts, p.P-7.
  33. Smusz, S.; Kurczab, R.; Bojarski, A.J.; The insight on molecular fingerprint nature – how to enhance the virtual screening performance?; VIIIth Joint Meeting on Medicinal Chemistry, 30.06-04.07.2013, Lublin, Poland, Book of Abstracts, p.P-46. Abstract Poster
  34. Ravna, A.W.; Gabrielsen, M.; Kurczab, R.; Kristiansen, K.; Freyd, T.; Kufaraeva, I.; Orvoll, E.O.; Lysaa, R.A.; Abagyan, R.; Nowak, G.; Chilmonczyk, Z.; Bojarski, A.; Sager, G.; Sylte, I.; Homology models in target-based virtual screening of membrane transporter proteins; Benzon Sympoisum No. 59 – Membrane Proteins: Structure, Function and Dynamics, 19-22.08.2013, Copenhagen, Denmark, Book of Abstracts, p.I-18.
  35. Zajdel, P.; Kurczab, R.; Canale, V.; Marciniec, K.; Grychowska, K.; Satała, G.; Pawłowski, M.; Bojarski, A.J.; Arylsulfonamide/amide derivatives of aryloxyethyl- and arylthioethyl piperidines and pyrrolidines as a novel class of potent 5-HT7 receptor antagonists;  Vth BBBB International Conference, 26-28.09.2013, Athens, Greece, Book of Abstracts, p.PP051.
  36. Smusz, S.; Kurczab, R.; Bojarski, A.J.; Composition of the set of inactives and the performance in the classification of bioactive compounds by machine learning methods; 5th Symposium of the Polish Bioinformatics Society, 25-27.05.2012, Gdańsk, Poland, Book of Abstracts, p. Talk3. Abstract Poster
  37. Kurczab, R.; Mordalski, S.; Kościółek, T.; Bojarski, A.J.; The novel approach in structure-based 3D pharmacophore model generation and its evaluation on 5-HT6R homology models; 5th Symposium of the Polish Bioinformatics Society, 25-27.05.2012, Gdańsk, Poland, Book of Abstracts, p.Talk20. Abstract Poster
  38. Zajdel, P.; Kurczab, R. ; Grychowska, K.; Szymiec, M.; Glanowski, G.; Kamiński, K.; Satała, G.; Pawłowski, M.; Bojarski, A.J.; The multiobjective based design, synthesis and evaluation of the arylsulfonamide/amide derivatives of arylxyethyl- and arylthioethyl piperidines and pyrrolidines as a novel class of potent 5-HT7 receptor antagonists; The Eight Multidisciplinary Conference on Drug Research, 30.05-01.06.2012, Rawa Mazowiecka, Poland, Book of Abstracts, p.74. Abstract
  39. Guzik, P.; Canale, V.; Verdie, P.; Kurczab, R.; Satała, G.; Pawłowski, M.; Martinez, J.; Subra, G.; Bojarski, A.J.; Zajdel, P.; Long-Chain Arylpiperazine Derivatives with Cyclic Amino Acid Amide Fragments as Potential 5-HT7 Receptor Ligands; The 5th Conversatory of Medicinal Chemistry, 13-15.09.2012, Lublin, Poland, Book of Abstracts, p.P-93.Abstract
  40. Zajdel, P.; Kurczab, R.; Grychowska, K.; Szymiec, M. ; Glanowski, G.; Satała, G.; Pawłowski, M.; Bojarski, A.J.; The Multiobjective Based Design, Synthesis and Evaluation of the Arylsulfonamide/amide Derivatives of Arylxyethyl- and Arylthioethyl Piperidines and Pyrrolidines as a Novel Class of Potent 5-HT7 Receptor Antagonists; The 5th Conversatory of Medicinal Chemistry, 13-15.09.2012, Lublin, Poland, Book of Abstracts, p.P-92.Abstract
  41. Smusz, S.; Kurczab, R. ; Bojarski, A.J.; Machine Learning Method as a Tool for Searching New 5-HT6 Ligands in Fingerprint-Based Consensus Experiment; The 5th Conversatory of Medicinal Chemistry, 13-15.09.2012, Lublin, Poland, Book of Abstracts, p.P-65. Abstract Poster
  42. Kurczab, R.; Warszycki, D.; Bojarski, A.J.; The Novel Approach in Structure-Based 3D Pharmacophore Model Generation. An Application to Searching for 5-HT6R Selectivity Hypothesis; The 5th Conversatory of Medicinal Chemistry, 13-15.09.2012, Lublin, Poland, Book of Abstracts, p.P-32. Abstract Poster
  43. Smusz, S.; Kurczab., R; Bojarski, A.J. The influence of hashed fingerprints density on the machine learning methods performance, The 8. German Conference on Cheminformatics, 11-13.11.2012, Goslar, Niemcy, Book of Abstracts: P-27. Abstract Poster
  44. Kurczab, R.; Smusz, S.; Bojarski A.J. The influence of training actives/inactives ratio on machine learning performance, The 8. German Conference on Cheminformatics, 11-13.11.2012, Goslar, Niemcy, Book of Abstracts: P-32. Abstract Poster
  45.  Smusz, S.; Kurczab, R.; Warszycki, D.; Kościółek, T.; Mordalski, S.; Bojarski, A.J.; Hybridization of ligands as a way of generating combinatorial libraries of drug candidates; Spring Congress of Polish Chemical Society Student Section, 13-17.04.2011, Murzasichle, Poland, Book of Abstracts, p.130. Abstract Poster
  46. Kurczab, R.; Bojarski, A.J.; The Multi-Conformations-Receptor-Based Pharmacophore Model Generation Schema and Its Potential Applications in Virtual Screening; 9th International Conference on Chemical Structures, 05-09.06.2011, Noordwijkerhout, The Netherlands, Book of Abstracts, p.126. Abstract Poster
  47. Warszycki, D.; Kristiansen, K.; Mordalski, S.; Kurczab, R.; Sylte, I.; Bojarski, A.J.; Comparison of various strategies in pharmacophore models generation – application to 5-HT1A receptor ligands; 9th International Conference on Chemical Structures, 05-09.06.2011, Noordwijkerhout, The Netherlands, Book of Abstracts, p.95. Abstract Poster
  48. Kurczab, R.; Mordalski, S.; Kościółek, T.; Bojarski, A.J.; The new strategy in structure-based pharmacophore model generation and its applications in virtual screening; VII Joint Meeting on Medicinal Chemistry, 26-27.06.2011, Catania, Italy, Book of Abstracts, p.187. Abstract Poster
  49. Warszycki, D.; Kristiansen, K.; Kurczab, R.; Satała, G.; Mordalski, S.; Sylte, I.; Bojarski, A.J.; Extensive pharmacophore modeling studies on 5-HT1A receptor ligands – single hypothesis vs. linear combinations; VII Joint Meeting on Medicinal Chemistry, 26-27.06.2011, Catania, Italy, Book of Abstracts, p.186. Abstract Poster
  50. Trela, M.; Bugno, R.; Kurczab, R.; Brański, P.; Bojarski, A.J.; New heterocyclic derivatives as potential allosteric modulators of group III metabotropic glutamate receptors; 4th International Symposium on Advances in Synthetic and Medicinal Chemistry, 21-25.08.2011, St. Petersburg, Russia, Book of Abstracts, p.220. Abstract Poster
  51. Warszycki, D.; Kristiansen, K.; Kurczab, R.; Mordalski, S.; Sylte, I.; Bojarski, A.J.; Linear Combination of Pharmacophore Hypotheses as a New Tool in Search of New 5-HT1A Receptor Ligands; The 4th Conversatory of Medicinal Chemistry, 08-10.09.2011, Lublin, Poland, Book of Abstracts, p.PP-4. Abstract Poster
  52. Kurczab, R.; Zajdel, P.; Pawłowski, M.; Bojarski, A.J.; Development and Validation of Methodology for Designing and Analysis of Virtual Combinatorial Libraries Based on Defined Reaction Pathways; The 4th Conversatory of Medicinal Chemistry, 08-10.09.2011, Lublin, Poland, Book of Abstracts, p.P-29. AbstractPoster
  53. Smusz, S.; Kurczab, R. ; Bojarski, A.J.; Meta-Learning as an Improvement of Machine Learning Methods Performance in Virtual Screening; The 4th Conversatory of Medicinal Chemistry, 08-10.09.2011, Lublin, Poland, Book of Abstracts, p.P-57.Abstract Poster
  54. Brański, P.; Bojarski, A.; Burnat, G.; Chorobik, P.; Bugno, R.; Kurczab, R.; Staroń, J.; Chruścicka, B.; Pałucha-Poniewiara, A.; Pilc, A.; Searching for a new potential mGluR4 positive allosteric modulators; 7th International Meeting on Metabotropic Glutamate Receptors, 02-07.10.2011 Taormina, Italy, Curr. Neuropharmacol., 2011, 9, Suppl. 1.
  55. Kurczab, R.; Gabrielsen, M.; Chilmonczyk, Z.; Sylte, I.; Bojarski, A.J.; Identification of Novel 5-HT7R Ligands via Multistep Virtual Screening of Commercially Available Compounds Databases; The Seventh Multidisciplinary Conference on Drug Research, 09-12.05.2010, Zakopane, Poland, Book of Abstracts, p.63. Abstract Poster
  56. Bugno, R.; Satała, G.; Duszyńska, B.; Kurczab, R.; Bojarski, A.J.; Examination of 5-HT6 receptor affinity in the group of arylsulfonamide derivatives; The Seventh Multidisciplinary Conference on Drug Research, 09-12.05.2010, Zakopane, Poland, Book of Abstracts, p.25. Abstract Poster
  57. Satała, G.; Bugno, R.; Duszyńska, B.; Kurczab, R.; Bojarski, A.J.; Verification of Virtual Screening Results for 5-HT6 Receptor in In Vitro Experiments; 3rd Conversatory on Medicinal Chemistry, 20-22.09.2010, Lublin, Poland, Book of Abstracts, p.PP-12. Abstract Poster
  58. Kurczab, R.; Smusz, S. ; Bojarski, A.J.; Evaluation of different Machine Learning Methods for Ligand-based Virtual Screening; German Conference on Chemoinformatics, 07-09.11.2010, Goslar, Germany, Book of Abstracts, p.105. Abstract
  59. Kurczab, R.; Nowak, M.; Jarończyk, M.; Chilmonczyk, Z. ; The development and validation of a novel virtual screening cascade protocol to identify potential serotonin 5-HT7R antagonists; 2nd Conversatory on Medicinal Chemistry, 08-10.09.2009, Lublin, Poland, Book of Astracts, p. P-25. Abstract Poster
  60. Kurczab, R.; Nowak, M.; Bojarski, A.J.; Comparison of FlexX and Surflex Docking Algorithms Based on Astex Diverse Set; 1st Conversatory on Medicinal Chemistry, 19-20.09.2008, Lublin, Poland, Book of Astracts, p.P-46. Abstract

b) speeches:

  1. Kurczab R., Evaluation of halogen bonding hot spots by virtual screening of commercial databases – a case study of 5-HT7R, 10th Joint Meeting on Medicinal Chemistry, 25–29.06.2017, Dubrovnik, Chorwacja, Book of Abstracts, OP-9
  2. Kurczab R., Wiązania halogenowe – od struktury krystalograficznej do racjonalnego projektowania nowych leków, XXXIV Szkoła Zimowa Instytutu Farmakologii PAN, 10-13.01.2017, Kraków
  3. Kurczab R., The potential of halogen bonding in class A of GPCRs: application of XB hot spots for rational design of 5-HT7R ligands, VIII Konwersatorium Chemii Medycznej, 15-17.09.2016, Lublin, Book of Abstracts, C-6
  4. Kurczab R., Halogen bonding – the role and significance in interaction s of ligands with class A GPCRs, 2nd International Symposium on Halogen Bonding,6-10.06.2016, Gothenburg, Szwecja, Book of Abstract, YR05
  5. Kurczab, R.; Bojarski, A.J.; The novel approach in structure-based 3D pharmacophore model generation and its potential applications in virtual screening; VIIIth Joint Meeting on Medicinal Chemistry, 30.06-04.07.2013, Lublin, Poland, Book of Abstracts, p.ML-XX. Abstract
  6. Kurczab, R.; Mordalski, S.; Kościółek, T.; Bojarski, A.J.; The novel approach in structure-based 3D pharmacophore model generation and its evaluation on 5-HT6R homology models; 5th Symposium of the Polish Bioinformatics Society, 25-27.05.2012, Gdańsk, Poland, Book of Abstracts, p.Talk20. Abstract Poster
  7. Kurczab, R.; Bojarski, A.J.; The searching of novel PAM of mGluR III by Virtual Screening of commercial chemical databases; The Twenty First Days of Neuropsychopharmacology, 10-13.06.2012, Ustroń-Jaszowiec, Poland, Pharmacological Reports, 2012, 64, p.473. Abstract
  8. Kurczab, R.; Bojarski, A.J.; How to find a needle in a haystack? The application of  in silico methods in searching of potentially new PAM of mGluR III; The Twentieth Days of Neuropsychopharmacology, 22-25.05.2011, Ustroń-Jaszowiec,Poland, Pharmacological Reports, 2011, 63, p.579. Abstract
  9. Kurczab, R.; Gabrielsen, M.; Chilmonczyk, Z.; Sylte, I.; Bojarski, A.; Virtual Screening Approach as a Potent Technology in Drug Design Campaigns. Methods, Applications and Computational Perspectives; 3rd Conversatory on Medicinal Chemistry, Book of Abstracts, p.L-3. Abstract

Awards:

  1. Laureate of the Polish Intelligent Development Award 2020 in the category: „The Researcher of the Future” for the project entitled „Polypharmacological in silico screening platform”.
  2. Scholarship for outstanding young scientists funded by the Ministry of Science and Higher Education.
  3. 2nd award for poster: „N-alkylated arylsulfonamides of (aryloxy)ethyl piperidines: 5-HT7 receptor selectivity vs multireceptor profile”, Canale V., Kurczab R., Satała G., Partyka A., Jastrzębska-Więsek M., Słoczyńska K., Kos T., Pękala E., Popik P., Bojarski A.J., Wesołowska A., Zajdel P., presented during the VIIth Meeting of Polish Medicinal Chemistry Society, 17-19.09.2015, Lublin.
  4. Best Norwegian publication of pharmacology in 2014 for article : Gabrielsen M., Kurczab R., Siwek A., Wolak M., Ravna A., Kristiansen K., Kufareva I., Abagyan R., Nowak G., Chilmonczyk Z., Sylte I., Bojarski A. J., Identification of Novel Serotonin Transporter Compounds by Virtual Screening, J. Chem. Inf. Model., 2014, 54, 933–943, awarded by the Norwegian Society for Pharmacology and Toxicology.
  5. 1st award for poster: “Design, synthesis and biological evaluation of novel combretastatin A-4 derivatives – potential antimitotic agents” Stefański T., Kurczab R., Dutkiewicz Z., Mikstacka R., Cichocki M., Murias M., Gielara-Korzańska A., Sobiak S., presented during, VIth Meeting of Polish Medicinal Chemistry Society, 18-20.09.2014, Lublin.
  6. The Janina Janikowa’s award for the best master theses in chemistry – awarded by Polish Chemical Society, Poland, 2009.
  7. Award for young, talented researcher – START Programme of the Foundation for Polish Science, Poland, 2012.