Publications 2018

 

        1. Tber, Z.; Wartenberg, M.; Jacques, J.E.; Roy, V.; Lecaille, F.; Warszycki, D.; Bojarski, A.J.; Lalmanach, G.; Agrofoglio, L.A. Selective inhibition of human cathepsin S by 2,4,6-trisubstituted 1,3,5-triazine analogs,

Bioorg. Med. Chem. 2018, 26

          , 4310-4319

https://www.ncbi.nlm.nih.gov/pubmed/30049585

                        )

2. Kelemen, Á.A.; Satała, G.; Bojarski, A.J.; Keserű, G.M. Spiro[pyrrolidine-3,3′-oxindoles] as 5-HT7 receptor ligands, Bioorg. Med. Chem. Lett. 2018, 28, 2418-2421 (https://www.ncbi.nlm.nih.gov/pubmed/29910079)

3. Staron, J.; Bugno, R.; Hogendorf, A. S.; Bojarski, A. J. 5-HT1A receptor ligands and their therapeutic applications: review of new patents. Expert. Opin. Ther. Pat. 2018, 28, 679-689 (https://www.ncbi.nlm.nih.gov/pubmed/30124346)

4. Pandy-Szekeres, G.; Munk, C.; Tsonkov, T. M.; Mordalski, S.; Harpsoe, K.; Hauser, A. S.; Bojarski, A. J.; Gloriam, D. E. GPCRdb in 2018: adding GPCR structure models and ligands. Nucleic Acids Res. 2018, 46, D440-D446 (https://www.ncbi.nlm.nih.gov/pubmed/29155946)

5. Stefanski, T.; Mikstacka, R.; Kurczab, R.; Dutkiewicz, Z.; Kucinska, M.; Murias, M.; Zielinska-Przyjemska, M.; Cichocki, M.; Teubert, A.; Kaczmarek, M.; Hogendorf, A.; Sobiak, S. Design, synthesis, and biological evaluation of novel combretastatin A-4 thio derivatives as microtubule targeting agents. Eur. J. Med. Chem. 2018, 144, 797-816 (https://www.ncbi.nlm.nih.gov/pubmed/29291446)

6. Satala, G.; Duszynska, B.; Lenda, T.; Nowak, G.; Bojarski, A. J. Allosteric Inhibition of Serotonin 5-HT7 Receptors by Zinc Ions. Mol. Neurobiol. 2018, 55, 2897-2910 (https://www.ncbi.nlm.nih.gov/pubmed/28455702)

7. Kucwaj-Brysz, K.; Kurczab, R.; Jastrzebska-Wiesek, M.; Zeslawska, E.; Satala, G.; Nitek, W.; Partyka, A.; Siwek, A.; Jankowska, A.; Wesolowska, A.; Kiec-Kononowicz, K.; Handzlik, J. Computer-aided insights into receptor-ligand interaction for novel 5-arylhydantoin derivatives as serotonin 5-HT7 receptor agents with antidepressant activity. Eur. J. Med. Chem. 2018, 147, 102-114 (https://www.ncbi.nlm.nih.gov/pubmed/29425815)

8. Staron, J.; Dabrowski, J. M.; Cichon, E.; Guzik, M. Lactose esters: synthesis and biotechnological applications. Crit. Rev. Biotechnol. 2018, 38, 245-258 (https://www.ncbi.nlm.nih.gov/pubmed/28585445)

9. Podlewska, S.; Kafel, R. MetStabOn-Online Platform for Metabolic Stability Predictions. Int. J. Mol. Sci. 2018, 19, 1040 (https://www.ncbi.nlm.nih.gov/pubmed/29601530)

10. Grychowska, K.; Kurczab, R.; Śliwa, P.; Satała, G.; Dubiel, K.; Matłoka, M.; Moszczyński-Pętkowski, R.; Pieczykolan, J.; Bojarski, A.J.; Zajdel, P. Pyrroloquinoline scaffold-based 5-HT6R ligands: Synthesis, quantum chemical and molecular dynamic studies, and influence of nitrogen atom position in the scaffold on affinity, Bioorg. Med. Chem. 2018, 26, 3588-3595 (https://www.ncbi.nlm.nih.gov/pubmed/29853337).

11. Kalinowska-Tluscik, J.; Staron, J.; Krawczuk, A.; Mordalski, S.; Warszycki, D.; Satala, G.; Hogendorf, A. S.; Bojarski, A. J. The effect of the intramolecular C-H/O interactions on the conformational preferences of bis-arylsulfones – 5-HT6 receptor antagonists and beyond. RSC Adv. 2018, 8, 18672-18681(https://pubs.rsc.org/en/content/articlelanding/2018/ra/c8ra03107j#!divAbstract).

12. Sliwa, P.; Kurczab, R.; Bojarski, A. J. ONIOM and FMO-EDA study of metabotropic glutamate receptor 1: Quantum insights into the allosteric binding site. Int. J. Quantum. Chem. 2018, 118, e25617 (https://onlinelibrary.wiley.com/doi/abs/10.1002/qua.25617)

13. Kucwaj-Brysz, K.; Kurczab, R.; Zeslawska, E.; Lubelska, A.; Marc, M. A.; Latacz, G.; Satala, G.; Nitek, W.; Kiec-Kononowicz, K.; Handzlik, J. The role of aryl-topology in balancing between selective and dual 5-HT7R/5-HT1A actions of 3,5-substituted hydantoins. Med. Chem. Commun. 2018, 9, 1033-1044 (https://www.ncbi.nlm.nih.gov/pubmed/30108992)

14. Lazewska, D.; Kaleta, M.; Hagenow, S.; Mogilski, S.; Latacz, G.; Karcz, T.; Lubelska, A.; Honkisz, E.; Handzlik, J.; Reiner, D.; Satala, G.; Filipek, B.; Stark, H.; Kiec-Kononowicz, K. Novel naphthyloxy derivatives – Potent histamine H3 receptor ligands. Synthesis and pharmacological evaluation. Bioorg. Med. Chem. 2018, 26, 2573-2585 (https://www.ncbi.nlm.nih.gov/pubmed/29681486)

15.  Kurczab, R.; Ali, W.; Lazewska, D.; Kotanska, M.; Jastrzebska-Wiesek, M.; Satala, G.; Wiecek, M.; Lubelska, A.; Latacz, G.; Partyka, A.; Starek, M.; Dabrowska, M.; Wesolowska, A.; Jacob, C.; Kiec-Kononowicz, K.; Handzlik, J. Computer-Aided Studies for Novel Arylhydantoin 1,3,5-Triazine Derivatives as 5-HT(6) Serotonin Receptor Ligands with Antidepressive-Like, Anxiolytic and Antiobesity Action In Vivo. Molecules 2018, 23, 2529 (https://www.ncbi.nlm.nih.gov/pubmed/30282913)

16. Kurczab, R.; Canale, V.; Satala, G.; Zajdel, P.; Bojarski, A. J. Amino Acid Hot Spots of Halogen Bonding: A Combined Theoretical and Experimental Case Study of the 5-HT7 Receptor. J. Med. Chem. 2018, 61, 8717-8733 (https://www.ncbi.nlm.nih.gov/pubmed/30188719)

17. Walory, J.; Mielczarek, L.; Jaronczyk, M.; Koronkiewicz, M.; Kossakowski, J.; Bugno, R.; Bojarski, A. J.; Chilmonczyk, Z. Oncotoxic Properties of Serotonin Transporter Inhibitors and 5-HT1A Receptor Ligands. Int. J. Mol. Sci. 2018, 19, 3260 (https://www.ncbi.nlm.nih.gov/pubmed/30347827)

18. Kelemen, A. A., Mordalski, S., Bojarski, A. J., Keseru, G. M. Computational modeling of drugs for Alzheimer’s disease: Design of serotonin 5-HT6 antagonists. In Computational Modeling of Drugs Against Alzheimer’s Disease; Roy, K. Eds.; Humana Press: New York, NY, 2018; p. 419-461 (https://link.springer.com/protocol/10.1007/978-1-4939-7404-7_15)

19. Kurek, J.; Kwasniewska-Sip, P.; Myszkowski, K.; Cofta, G.; Murias, M.; Barczynski, P.; Jasiewicz, B.; Kurczab, R. 7-Deacetyl-10-alkylthiocolchicine derivatives – new compounds with potent anticancer and fungicidal activity. Med. Chem. Commun. 2018, 9, 1708-1714 (https://www.ncbi.nlm.nih.gov/pubmed/30429975)

20. Cieslik, P.; Wozniak, M.; Kaczorowska, K.; Branski, P.; Burnat, G.; Chocyk, A.; Bobula, B.; Gruca, P.; Litwa, E.; Palucha-Poniewiera, A.; Wasik, A.; Pilc, A.; Wieronska, J. Negative Allosteric Modulators of mGlu7 Receptor as Putative Antipsychotic Drugs. Front Mol. Neurosci. 2018, 20, 316 (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158327/)

21. Rataj, K.; Czarnecki, W.; Podlewska, S.; Pocha, A.; Bojarski, A.J. Substructural Connectivity Fingerprint and Extreme Entropy Machines-A New Method of Compound Representation and Analysis, Molecules. 2018, 23, E1242 (https://www.ncbi.nlm.nih.gov/pubmed/29789513).

22. Marciniec, K.; Kurczab, R.; Książek, M.; Bębenek, E.; Chrobak, E.; Satała, G.; Bojarski, A. J.; Kusz, J., Zajdel, P. Structural determinants influencing halogen bonding: a case study on azinesulfonamide analogs of aripiprazole as 5-HT1A, 5-HT7, and D2 receptor ligands, Chem. Cent. J. 2018, 12, 55 (https://www.ncbi.nlm.nih.gov/pubmed/29748774).

23. Rataj, K.; Kelemen, Á.A.; Brea, J.; Loza, M.I.; Bojarski, A.J.; Keserű, G.M. Fingerprint-Based Machine Learning Approach to Identify Potent and Selective 5-HT2BR Ligands, Molecules, 2018, 23, E1137 (https://www.ncbi.nlm.nih.gov/pubmed/29748476).

24. Podlewska, S.; Kafel, R.; Lacivita, E.; Satała, G.; Kooistra, A.J.; Vass, M.; de Graaf, C.; Leopoldo, M.; Bojarski, A.J.; Mordalski S. Structural insights into serotonin receptor ligands polypharmacology, Eur. J. Med. Chem. 2018, 151, 797-814. (https://www.ncbi.nlm.nih.gov/pubmed/29679900).

25. Zajdel, P.; Kos, T.; Marciniec, K.; Satała, G.; Canale, V.; Kamiński, K.; Hołuj, M.; Lenda, T.; Koralewski, R.; Bednarski, M.; Nowiński, L.; Wójcikowski, J.; Daniel, W.A.; Nikiforuk, A.; Nalepa, I.; Chmielarz, P.; Kuśmierczyk, J.; Bojarski, A.J.; Popik, P. Novel multi-target azinesulfonamides of cyclic amine derivatives as potential antipsychotics with pro-social and pro-cognitive effects, Eur. J. Med. Chem. 2018, 145, 790-804 (https://www.ncbi.nlm.nih.gov/pubmed/29407591)

26.  Vanda, D.; Soural, M.; Canale, V.; Chaumont-Dubel, S.; Satała, G.; Kos, T.; Funk, P.; Fülöpová, V.; Lemrová, B.; Koczurkiewicz, P.; Pękala, E.; Bojarski, A.J.; Popik, P.; Marin, P.; Zajdel, P.  Novel non-sulfonamide 5-HT6 receptor partial inverse agonist in a group of imidazo[4,5-b]pyridines with cognition enhancing properties. Eur. J. Med. Chem. 2018, 144, 716-729 (https://www.ncbi.nlm.nih.gov/pubmed/29291439