Dawid Warszycki, MSc

 

e-mail: warszyc@if-pan.krakow.pl
phone: +4812 66 23 301

 

 

 Research interests:

  • computer aided drug design
  • pharmacophore modeling
  • bioisosterism
  • virtual screening
  • machine learning
  • homology modelling
  • GPCR

 

Scientific career:

  • From 05.2010 – employed at the Institute of Pharmacology, Polish Academy of Sciences in Cracow, Department of Medicinal Chemistry, position: engineering and technology.
  • 10.2008-06.2010 – second level studies, course: chemistry,  Institute de Chimie Organique at Analityque Universite d’Orleans, obtained degree: Master of Science (06.2012)
  • 10.2005-06.2010 – full-time master′s course, course: chemistry, Faculty of Chemistry of the Jagiellonian University in Cracow, obtained degree: Master of Science (06.2012)

Publications:

  1. Bessieres, M., Sari, O.; Roy, V.; Warszycki, D.; Bojarski, A.J., Nolan S.P.;, Snoeck, R.; Andrei, G.; Schinazi, R.F.; Agrofoglio, L. Sonication-Assisted Synthesis of (E)-2-Methyl-but-2-enyl Nucleoside Phosphonate Prodrugs, ChemistrySelect 2016, 1, 3108 – 3113
  2. Staroń, J.; Warszycki, D.;, Kurczab, R.; Satała, G.; Bugno, R.; Hogendorf, A.; Bojarski, A.J. Halogen bonding enhances activity in a series of dual 5-HT6/D2 ligands designed in a hybrid bioisostere generation/virtual screening protocol. RSC Advances, 2016, 6, 54918-54925 (http://pubs.rsc.org/en/content/articlelanding/2016/ra/c6ra08714k#!divAbstract)
  3. Śmieja, M.; Warszycki, D.;. Average Information Content Maximization—A New Approach for Fingerprint Hybridization and Reduction. PLoS One. 2016, Jan 11(1):e0146666
  4. Kucwaj-Brysz, K.; Warszycki, D.; Podlewska, S.; Witek, J.; Witek, K.; González Izquierdo, A.; Satała, G.; Loza, M.I.; Lubelska, A.; Latacz, G.; Bojarski, A.J.; Castro, M.; Kieć-Kononowicz, K.; Handzlik, J. Rational design in search for 5-phenylhydantoin selective 5-HT7R antagonists. Molecular modeling, synthesis and biological evaluation, Eur. J. Med. Chem., 2016, 112, 258-269 (http://www.ncbi.nlm.nih.gov/pubmed/26900658)
  5. Plebanek, E.; Chevrier, F.; Roy, V.; Garenne, T.; Lecaille, F.; Warszycki, D.; Bojarski, A.J.; Lalmanach, G.; Agrofoglio, L.A. Straightforward synthesis of 2,4,6-trisubstituted 1,3,5-triazine compounds targeting cysteine cathepsins K and S., Eur. J. Med. Chem., 2016, 121, 12-20 (http://www.ncbi.nlm.nih.gov/pubmed/27214508)
  6. Smusz, S.; Czarnecki, W. M.; Warszycki, D.; Bojarski, A. J. Exploiting uncertainty measures in compounds activity prediction using support vector machines. Bioorg. Med. Chem. Lett. 2015, 25, 100-105 (http://www.ncbi.nlm.nih.gov/pubmed/25466199)
  7. Warszycki, D.; Mordalski, S.; Staroń, J.; Bojarski, A.J. Bioisosteric matrices for ligands of serotonin receptors.  ChemMedChem. 2015 10, 601-605. (http://www.ncbi.nlm.nih.gov/pubmed/25772514)
  8. Staroń, J.; Warszycki, D.; Kalinowska-Tłuścik, J.; Satała, G.; Bojarski, A. J. Rational design of 5-HT6R ligands using a bioisosteric strategy: synthesis, biological evaluation and molecular modelling. RSC Advances 2015, 5, 25806-25815 (http://pubs.rsc.org/en/content/articlelanding/2015/ra/c5ra00054h#!divAbstract)
  9. Kurczyk, A.; Warszycki, D.; Musiol, R.; Kafel, R.; Bojarski, A.J.; Polanski, J. Ligand-Based Virtual Screening in a Search for Novel Anti-HIV-1 Chemotypes. J. Chem. Inf. Model. 201510, 2168-2177 (http://www.ncbi.nlm.nih.gov/pubmed/26431196).
  10. Śmieja, M.; Warszycki, D.; Tabor, J.; Bojarski A. J. Asymmetric clustering index in a case study of 5-HT1A receptor ligands. PLoS One 20149, e102069 (http://www.ncbi.nlm.nih.gov/pubmed/25019251)
  11. Warszycki, D.; Mordalski, S.; Kristiansen, K.; Kafel, R.; Sylte, I.; Chilmonczyk, Z.; Bojarski, A. J. A Linear Combination of Pharmacophore Hypotheses as a New Tool in Search of New Active Compounds – An Application for 5-HT1A Receptor Ligands. PLoS. One. 2013, 8, e84510 (http://www.ncbi.nlm.nih.gov/pubmed/24367669)
  12. Kaczor, A; Reva, I.; Warszycki, D.; Fausto, R. UV-induced cyclization in myrcene isolated in rigid argon environment: FT-IR and DFT study. Journal of Photochemistry and Photobiology A: Chemistry. 2011, 222, 1-9 (http://www.sciencedirect.com/science/article/pii/S1010603011000694)

Participation in research projects:

  • EXtention of academia-based PLATFORM to antidepressant hits discovery (PLATFORMex), Pol-Nor/198887/73/2013, function: executor, 2013 –
  • Innovative therapies for neurodegenerative and neurodevelopmental diseases based on mGlu receptor allosteric modulators – Allosterix, NCBiR 178469, function: executor, 2013 –
  • Demeter – Depression – mechanisms – therapy, WND-POIG.01.01.02-12.004/09 (www.de-me-ter.pl), function: executor, 2010-2014.
  • Allosteric modulation – new strategy in pharmacotherapy. Identification of the psychotropic properties of glutamatergic receptor ligands of group III. WND-POIG.01.03.01-12-100/08 (www.modall.pl), function: executor, 2011-2012.
  • Creating an academia-based platform to discover substances acting on serotonergic or glutamatergic systems as potential new antidepressant or anxiolytic drugs. PNRF-103-AI-1/07 (www.cns-platform.eu), function: executor, 2010-2011.
  • Antagonists of 5-HT6 receptor as advanced antipsychotic drugs with procognitive properties, UDA-POIG.01.03.01-12-063/09-02 (www.prokog.pl), function: executor, 2010-2013.

Scientific reports:

a) posters:

  1. Freyd, T.; Evenseth, L.M.; Wushur, I.; Gabrielsen, M.; Warszycki, D.; Mordalski, S.; Brański, P.;Chruścicka, B.; Burnat, G.; Pilc, A.; Bojarski, A.J.; Sylte, I.; Screening for new GABAB receptor compounds; Glisten 2016 Prague, 26-27.09.2016, Prague, Czech Republic, Book of Abstracts Abstract
  2. Warszycki, D.; Rataj, K.; Gloriam, D.E.; Bojarski, A.J.; Mordalski, S.; Selection of the most significant ligand-receptor interactions in GPCRs crystal complexes; Glisten 2016 Prague, 26-27.09.2016, Prague, Czech Republic, Book of Abstracts Abstract Poster
  3. Freyd, T.; Warszycki, D.; Gabrielsen, M.; Mordalski, S.; Bojarski, A.J.; Sylte, I.; Allosteric modulation of the human GABAB receptor; VIIIth Conversatory on Medicinal Chemistry, 15-17.09.2016, Lublin, Poland, Book of Abstracts, p.P118 Abstract Poster
  4. Bugno, R.; Staroń, J.; Hogendorf, A.S.; Satała, G.; Warszycki, D.; Mordalski, S.; Bojarski, A.J.; Synthesis and evaluation of a new indole-based series as nonbasic 5-HT6 receptor ligands; VIIIth Conversatory on Medicinal Chemistry, 15-17.09.2016, Lublin, Poland, Book of Abstracts, p.P95 Abstract Poster
  5. Warszycki, D.; Agrofoglio, L.; Roy, V.; Bojarski, A.J. ; Application of linear combination of pharmacophore models in modeling and screening of UDP-N-acetylmuramoylalanine glutamate ligase inhibitors; VIIIth Conversatory on Medicinal Chemistry, 15-17.09.2016, Lublin, Poland, Book of Abstracts, p.P33 Abstract Poster
  6. Staroń, J.; Warszycki, D.; Kurczab, R.; Satała, G.; Kalinowska-Tłuścik, J.; Bojarski, A.J.;Serendipity discoveries in medicinal chemistry; a case of 5-HT6R ligands. Bioisosterism, organic synthesis, crystal structures and molecular modelling.; 3rd EFMC Young Medicinal Chemist Symposium, 28.08.01.09.2016, Manchester, United Kingdom, Book of Abstracts
  7. Staroń, J.; Satała, G.; Warszycki, D.; Bojarski, A.J.; A non-basic 5-HT6R antagonists; XXIV EFMC International Symposium on Medicinal Chemistry, 28.08.01.09.2016, Manchester, United Kingdom, Book of Abstracts
  8. Bugno, R.; Strekowska, A.; Hogendorf, A.S.; Satała, G.; Warszycki, D.; Mordalski, S.;Bojarski, A.J.; Design, synthesis and structure-activity relationships of 1-(arylsulfonyl)-1H-indole derivatives as non-basic 5-HT6 receptor ligands;  XXIV EFMC International Symposium on Medicinal Chemistry, 28.08.01.09.2016, Manchester, United Kingdom, Book of Abstracts
  9. Warszycki, D.; Roy, V. ; Bojarski, A.J.; Agrofoglio, L.; Virtual screening cascade in search for novel purine-derivated Mur D inhibitors as antibacterial agents; 22 International Round Table on Nucleosides, Nucleotides and Nucleic Acids (XXII IRT), 18-22.07.2016, Paris, France, Book of Abstracts Abstract Poster
  10. Staroń, J.; Kurczab, R.; Warszycki, D.; Satała, G.; Bugno, R.; Hogendorf, A.; Bojarski, A.J.;Halogen bonding enhances affinity at 5-HT7R in a series of N-[2-(dimethylamine)ethyl]-N-(2-phenylehtyl)anilines; 2nd Central European Biomedical Congress (CEBC), 15-18.06.2016, Kraków, Poland, Book of Abstracts, p.135
  11. Warszycki, D.; Roy, V. ; Agrofoglio, L.; Bojarski, A.J.; Pharmacophore modeling of UDP-N-acetylmuramoylalanine glutamate ligase inhibitors – methodology and application for virtual screening procedure; 2nd Central European Biomedical Congress (CEBC), 15-18.06.2016, Kraków, Poland, Book of Abstracts, p.41
  12. Warszycki, D.; Smieja, M.; Bojarski, A.J.; Tabor, J.; Mean Information Content (MIC) algorithm – a new approach for fingerprint hybridization and reduction; 11th German Conference on Chemoinformatics, 08-10.11.2015, Fulda, Germany, Book of Abstracts, p.P24
  13. Podlewska, S.; Warszycki, D.; Bojarski, A.J.; Because two is always better than one – towards the search of dual 5-HTx-SERT ligands ; GLISTEN Meeting Amsterdam 2015, 12-13.10.2015, Amsterdam, The Netherlands, Book of Abstracts, p.25 Abstract Poster
  14. Warszycki, D.; Kafel, R.; Bojarski, A.J.; Application of linear combination of pharmacophore hypotheses into search for the dual 5-T1A/SERT ligands; GLISTEN Meeting Amsterdam 2015, 12-13.10.2015, Amsterdam, The Netherlands, Book of Abstracts, p.36 Abstract Poster
  15. Bugno, R.; Staroń, J.; Hogendorf, A.; Satała, G.; Warszycki, D.; Mordalski, S.; Bojarski, A.J.; Non-basic 5-HT6 Receptor Ligands; VIIth Conversatory on Medicinal Chemistry; VIIth Conversatory on Medicinal Chemistry, 17-19.09.2015, Lublin, Poland, Book of Abstracts, p.PP7 Abstract Poster
  16. Warszycki, D.; Rataj, K.; Bojarski, A.J.; An analysis of molecular interactions between the 5-HT6 receptor and non-basic ligands; VIIth Conversatory on Medicinal Chemistry, 17-19.09.2015, Lublin, Poland, Book of Abstracts, p.P102 Abstract Poster
  17. Staroń, J.; Warszycki, D.; Satała, G.; Bojarski, A.J.; Derivatives of N-[2-(dimethylamine)ethyl]-N-(2-phenylethyl)-aniline as potential polypharmacological ligands of SERT/5-HT6/5-HT7; VIIth Conversatory on Medicinal Chemistry, 17-19.09.2015, Lublin, Poland, Book of Abstracts, p.P92 Abstract Poster
  18. Hogendorf, A.; Bugno, R.; Satała, G.; Hogendorf, A.; Staroń, J.; Warszycki, D.; Bojarski, A.J.; Design and synthesis of aminergic GPCR’s ligands; Naukowe Doktorantów III Edycja, 18.04.2015, Kraków, Poland, Book of Abstracts, p.24 Abstract
  19. Hogendorf, A.; Satała, G.; Staroń, J.; Hogendorf, A.; Bugno, R.; Warszycki, D.; Bojarski, A.J.; Three point pharmacophore investigation leads to novel serotonergic chemotypes; GLISTEN Spring Meeting 2015, 01-02.04.2015, Allschwil, Switzerland, Book of Abstracts, p.44
  20. Kucwaj-Brysz, K.; Warszycki, D.; Witek, J.; Smusz, S.; Satała, G.; Bojarski, A.J.; Handzlik, J.; Kieć-Kononowicz, K.; Hydantoin derivatives as selective serotonin 5-HT7 receptor ligands; The GLISTEN Budapest 2014 Conference, 02-04.10.2014, Budapest, Hungary, Book of Abstracts, p.P416 Abstract
  21. Warszycki, D.; Mordalski, S.; Freyd, T.; Sylte, I.; Bojarski, A.J.; Pharmacophore modeling of GABA-B receptor ligands – methodology and application for virtual screening; The GLISTEN Budapest 2014 Conference, 02-04.10.2014, Budapest, Hungary,  Book of Abstracts, p.P407 Abstract Poster
  22. Warszycki, D.; Staroń, J.; Kafel, R.; Bojarski, A.J.; Lessons learned from analysis of bioisosteric substitution in ligands of serotonin receptor family; VIth Conversatory on Medicinal Chemistry, 18-20.09.2014, Lublin, Poland, Book of Abstracts, p.188 Abstract Poster
  23. Staroń, J.; Warszycki, D.; Kalinowska-Tłuścik, J.; Satała, G.; Bojarski, A.J.; Investigation of Ligand Binding Mode at 5-HT6R with the Use of Bioisosterism ; The XXIII International Symposium on Medicinal Chemistry (EFMC-ISMC 2014), 07-11.09.2014, Lisbon, Portugal, Book of Abstracts, p.129 Abstract Poster
  24. Freyd, T.; Warszycki, D.; Gabrielsen, M.; Kristiansen, K.; Chilmonczyk, Z.; Bojarski, A.J.;Sylte, I.; Allosteric modulation of the human GABAB receptor: Development of a tool for antidepressant drug discovery; The 5th Annual BioStruct Conference, 28-31.08.2014, Jagtvolden, Norway,  Book of Abstracts, p.22 Abstract
  25. Warszycki, D.; Staroń, J.; Kafel, R.; Bojarski, A.J.; Comprehensive analysis of bioisosteric replacement in ligands of a serotonin receptors family; The 10th International Conference on Chemical Structures, 01-05.06.2014, Noordwijkerhout, the Netherlands,  Book of Abstracts, p.90 Abstract
  26. Kucwaj-Brysz, K.; Warszycki, D.; Satała, G.; Bojarski, A.J.; Handzlik, J.; Kieć-Kononowicz, K.; Poszukiwanie selektywnych ligandów receptora serotoninowego 5-HT7 pośród aminoalkilowych pochodnych hydantoiny; 29-30.05.2014, Kraków, Polska, Zeszyty Naukowe Towarzystwa Doktorantów UJ, Nr 8, p.118 Abstract
  27. Freyd, T.; Warszycki, D.; Gabrielsen, M.; Mordalski, S.; Kristiansen, K.; Chilmonczyk, Z.;Bojarski, A.J.; Sylte, I.; Allosteric modulation of the human GABA B receptor; GPCR Structure, Function and Drug Discovery Conference, 19-26.05.2014, Cambridge, USA,  Book of Abstracts
  28. Smusz, S.; Czarnecki, W.; Warszycki, D.; Bojarski, A.J.; Uncertainty of the in vitro experiments in the predictive models construction; GPCR Spring Conference 2014, 28-30.04.2014, Barcelona, Spain, Book of Abstracts, p.32 Poster
  29. Warszycki, D.; Rueada, M.; Kristiansen, K.; Sylte, I.; Abagyan, R.; Bojarski, A.J.; Ligand binding mode analysis using new 5-HT1A receptor models developed by ALiBERO methodology; GPCR Spring Conference 2014, 28-30.04.2014, Barcelona, Spain,  Book of Abstracts, p. 23 Poster
  30. Warszycki, D.; Rueada, M.; Kristiansen, K.; Sylte, I.; Abagyan, R.; Bojarski, A.; From homology models on raw templates to a set of ALiBERO binding pockets – a 5-HT1A receptor case study; GPCR-Ligand Interactions, Structures, and Transmembrane Signalling: a European Research Network, 07-09.10.2013, Warsaw, Poland, Poster
  31. Staroń, J.; Warszycki, D.; Kalinowska-Tłuścik, J.; Satała, G.; Bojarski, A.J.; The use of bioisosteric strategy to design and analyse 5-HT6 ligands binding mode;  III Konferencja Naukowa Doktorantów Wydziału Lekarskiego i Farmaceutycznego UJ CM, 09-10.05.2013, Zeszyty Naukowe Towarzystwa Doktorantów Uniwersytetu Jagiellońskiego, Nauki Ścisłe, Nr 6 (1/2013), p.164. Poster
  32. Kurczyk, A.; Warszycki, D.; Kafel, R.; Musioł, R.; Bojarski, A.J.; Polański, J.; Development of Multistep Ligand-Based Virtual Screening Cascade Methodology in a Search for Novel HIV-1 Integrase nhibitors: 1. Machine Learning; The 5th Conversatory of Medicinal Chemistry, 13-15.09.2012, Lublin, Poland, Book of Abstracts, p.P-33.Abstract
  33. Kurczab, R.; Warszycki, D.; Bojarski, A.J.; The Novel Approach in Structure-Based 3D Pharmacophore Model Generation. An Application to Searching for 5-HT6R Selectivity Hypothesis; The 5th Conversatory of Medicinal Chemistry, 13-15.09.2012, Lublin, Poland, Book of Abstracts, p.P-32. Abstract Poster
  34. Warszycki, D.; Kurczyk, A.; Kafel, R.; Musioł, R.; Bojarski, A.J.; Polański, J.; Development of Multistep Ligand-Based Virtual Screening Cascade Methodology in a Search for Novel HIV-1 Integrase Inhibitors: 2. Privileged Fragments; The 5th Conversatory of Medicinal Chemistry, 13-15.09.2012, Lublin, Poland, Book of Abstracts, p.C-7. Abstract Poster
  35. Warszycki, D.; Satała, G.; Staroń, J.; Bojarski, A.J.; Bioisosteric replacement in search for novel 5-HT6R ligands; 5th Symposium of the Polish Bioinformatics Society, 25-27.05.2012, Gdańsk, Poland, Book of Abstracts, p.Talk19. Abstract Poster
  36. Warszycki, D.; Kristiansen, K.; Kurczab, R.; Mordalski, S.; Sylte, I.; Bojarski, A.J.; Linear Combination of Pharmacophore Hypotheses as a New Tool in Search of New 5-HT1A Receptor Ligands; The 4th Conversatory of Medicinal Chemistry, 08-10.09.2011, Lublin, Poland, Book of Abstracts, p.PP-4. Abstract Poster
  37. Staroń, J.; Warszycki, D.; Satała, G.; Bugno, R.; Bojarski, A.J.; Bioisosterism, the use in designing 5-HT6 receptor ligands; 4th International Symposium on Advances in Synthetic and Medicinal Chemistry, 21-25.08.2011, St. Petersburg, Russia, Book of Abstracts, p.176. Abstract Poster
  38. Warszycki, D.; Kristiansen, K.; Kurczab, R.; Satała, G.; Mordalski, S.; Sylte, I.; Bojarski, A.J.; Extensive pharmacophore modeling studies on 5-HT1A receptor ligands – single hypothesis vs. linear combinations; VII Joint Meeting on Medicinal Chemistry, 26-27.06.2011, Catania, Italy, Book of Abstracts, p.186. Abstract Poster
  39. Warszycki, D.; Kristiansen, K.; Mordalski, S.; Kurczab, R.; Sylte, I.; Bojarski, A.J.; Comparison of various strategies in pharmacophore models generation – application to 5-HT1A receptor ligands; 9th International Conference on Chemical Structures, 05-09.06.2011, Noordwijkerhout, The Netherlands, Book of Abstracts, p.95. Abstract Poster
  40. Kristiansen, K.; Rueada, M.; Warszycki, D.; Kurczab, R.; Gabrielsen, M.; Abagyan, R.; Bojarski, A.J.; Sylte, I.; Modeling of ligand interactions for the human 5-HT1A receptor. Docking, pharmacophores and virtual screening of databases containing drug-like compounds; The 47th Norwegian Biochemical Society (NBS) contact meeting, 03-06.02.2011, Norway, Book of Abstracts, p.108. Abstract
  41. Smusz, S.; Kurczab, R.; Warszycki, D.; Kościółek, T.; Mordalski, S.; Bojarski, A.J.; Hybridization of ligands as a way of generating combinatorial libraries of drug candidates; Spring Congress of Polish Chemical Society Student Section, 13-17.04.2011, Murzasichle, Poland, Book of Abstracts, p.130. Abstract Poster
  42. Prymula, K; Kościółek, T.; Kurczab, R.; Mordalski, S.; Satała, G.; Warszycki, D. Bojarski, A.J.; New strategy for use of pharmacophore models in virtual screening for 5-HT6 receptor ligands, The 3rd Conversatory of Medicinal Chemistry, September 20–22, 2010, Lublin, Poland

b) speeches:

  1. Warszycki, D.; Kurczyk, A.; Kafel, R.; Musioł, R.; Bojarski, A.J.; Polański, J.; Development of Multistep Ligand-Based Virtual Screening Cascade Methodology in a Search for Novel HIV-1 Integrase Inhibitors: 2. Privileged Fragments; The 5th Conversatory of Medicinal Chemistry, 13-15.09.2012, Lublin, Poland, Book of Abstracts, p.C-7. Abstract Poster
  2. Warszycki, D.; Satała, G.; Staroń, J.; Bojarski, A.J.; Bioisosteric replacement in search for novel 5-HT6R ligands; 5th Symposium of the Polish Bioinformatics Society, 25-27.05.2012, Gdańsk, Poland, Book of Abstracts, p.Talk19. Abstract Poster
  3. Warszycki, D.; Kristiansen, K.; Kurczab, R.; Mordalski, S.; Sylte, I.; Bojarski, A.J.; Linear Combination of Pharmacophore Hypotheses as a New Tool in Search of New 5-HT1A Receptor Ligands; poster presentation, The 4th Conversatory of Medicinal Chemistry, 08-10.09.2011, Lublin, Poland, Book of Abstracts, p.PP-4. Abstract Poster
  4. Warszycki, D.; Prymula, K.; Kurczab, R.; Satała, G.; Bojarski, A.J.; The Implementation of an Expert System to Search for Novel Substances Acting on Serotonergic and Glutamatergic Systems; 3rd Conversatory of Medicinal Chemistry, September 20–22, 2010, Lublin, Poland, Book of Abstracts, p.K-3. Abstract

Experience gained in Poland:

Institute of Catalysis and Surface Chemistry Polish Academy of Sciences Cracow – Department of Zeolite Chemistry I, 16.07.2009 – 14.08.2009 (student practice)

Experience gained abroad:

  • France, Institute di Chimie Organique et Analityque,University of Orleans, 15.09.2009-15.03.2010
  • Norway, Medical Pharmacology and Toxicology, Department of Medical Biology, Faculty of Health Science, University of Tromsø, 14-22.11.2010
  • Norway, Medical Pharmacology and Toxicology, Department of Medical Biology, Faculty of Health Science, University of Tromsø, 12-21.09.2011
  • France, Institute di Chimie Organique et Analityque,University of Orleans, 25.05-02.06.2012
  • France, Institute di Chimie Organique et Analityque,University of Orleans, 02-05.12.2012
  • France, Institute di Chimie Organique et Analityque,University of Orleans, 16.11.2015-15.04.2016