Agata Hogendorf

Missing photo

Agata Hogendorf, MSc
e-mail: agata.hogendorf@gmail.com

Research interests:

  • Heterocyclic chemistry
  • Total synthesis
  • Transition metal catalysis in organic chemistry
  • CNS drugs
  • Allosteric modulators of GPCR’s

Scientific career:

  • from 09.2014: Research assistant, Medicinal Chemistry, IP PAS
  • 2011–2014 Master of Science, Faculty of Chemistry, Jagiellonian University
  • 2008–2011 Bachelor of Science, Faculty of Chemistry, Jagiellonian University

Patent Applications:

  1. Hogendorf, A.S.; Hogendorf, A.; Bojarski, A.J.; Satała, G.; Kurczab, R; Lenda, T.; Bugno, R.; Staroń, J. Imidazolyl-substituted indole derivatives binding 5-HT7 serotonin receptor and pharmaceutical compositions thereof. EP16461543.7
  2. Hogendorf, A.S.; Stankiewicz, A.; Brański, P.; Burnat, G.; Bugno, R.; Hogendorf, A.; Trela, M.; Pilc, A.; Bojarski, A.J. The substituted indole- or indazole-based mGluR8-positive allosteric modulators and their medical use. EP16461558.5
  3. Hogendorf, A. S.; Hogendorf, A.; Kurczab, R.; Satała, G.; Lenda, T.; Walczak, M.; Latacz, G.; Handzlik, J.; Kieć-Kononowicz, K.; Wierońska, J.; Woźniak, M.; Cieślik, P.; Bugno, R.; Staroń, J.; Bojarski, A. J. Low-basicity 5-HT7 Receptor Agonists Synthesized Using the van Leusen Multicomponent Protocol Sci. Rep. 2017, 7, Article number: 1444 (http://www.nature.com/articles/s41598-017-00822-4).

Scientific reports:

a) posters:

  1. Hogendorf, A.S.; Hogendorf, A.; Kurczab, R.; Satała, G.; Lenda, T.; Latacz, G.; Bugno, R.; Staroń, J.; Bojarski, A.J. Low-basicity 5-HT7 agonists as potential molecular probes, PET-radiotracers or pharmacological drugs. XXIV EFMC International Symposium on Medicinal Chemistry, 28.08-01.09 2016, Manchester, England, Book of abstracts, P513
  2. Hogendorf A.S.; Hogendorf, A.; Kurczab, R.; Satała, G.; Lenda, T.; Latacz, G.; Bugno, R.; Staroń. J.; Bojarski, A.J. Determining the binding mode of 3-(1-alkyl-1H-imidazol-5-yl)-1H-indoles. 3rd EFMC Young Medicinal Chemist Symposium, 01.09-03.09 2016, Manchester, England, Book of abstracts, FP16
  3. Hogendorf, A.; Hogendorf, A.S.; Kurczab, R.; Satała, G.; Bojarski, A.J. Binding mode analysis of a series of novel 5-HT1A ligands. VIII Conversatory on Medicinal Chemistry, 15-17.09.2016, Lublin, Poland, Book of abstracts, P4
  4. Hogendorf, A.S.; Hogendorf, A.; Kurczab, R.; Satała, G.; Lenda, T.; Latacz, G.; Bugno, R.; Staroń, J.; Bojarski, A.J. Low-basicity agonists of 5-HT7 receptor synthesized by van Leusen multicomponent reaction. VIII Conversatory on Medicinal Chemistry, 15.09-17.09.2016, Lublin, Poland, Book of abstracts, NS3
  5. Hogendorf, A.S.; Brański, P.; Burnat, G.; Bugno, R.; Hogendorf, A.; Chruścicka, B.; Stankiewicz, A.; Trela, M.; Bojarski, A.J. Positive allosteric modulators of mGluR8: design and development. 6th EFMC International Symposium on Advances in Synthetic and Medicinal Chemistry, 15-18.11.2015, Rehovot, Israel, Book of abstracts, P040
  6. Hogendorf, A.S.; Brański, P.; Burnat, G.; Bugno, R.; Hogendorf, A.; Chruścicka, B.; Bojarski, A.J. The development of mGluR8 PAM agonists. VII Conversatory on Medicinal Chemistry, 17-19.09.2015, Lublin, Poland, Book of abstracts, PP13
  7. Hogendorf, A.; Hogendorf, A.S.; Bojarski, A.J. The synthesis of fused heterocyclic building blocks and their application as core structures of GPCR ligands. VII Conversatory on Medicinal Chemistry, 17-19.09.2015, Lublin, Poland, Book of abstracts, P42
  8. Hogendorf, A.S.; Brański, P.; Burnat, G.; Bugno, R.; Hogendorf, A.; Chruścicka, B.; Bojarski, A.J. Finding allosteric modulators of metabotropic glutamate receptors as potential CNS drugs. V Meeting of the Paul Ehrlich MedChem Euro-PhD Network, 03-05.07.2015, Kraków, Poland, Book of abstracts, p.P-15
  9. Hogendorf, A.S.; Bugno,R.; Satała, G.; Hogendorf, A.; Staroń, J.; Warszycki, D.; Bojarski, A.J. Design and synthesis of aminergic GPCR’s ligands. Dokonania Naukowe Doktorantów III Edycja, 18.04.2015, Kraków, Poland, Book of abstracts, P24
  10. Hogendorf, A.S.; Satała, G.; Staroń, J.; Hogendorf, A.; Bugno, R.; Warszycki, D.; Bojarski, A.J. Three point pharmacophore investigation leads to novel serotonergic chemotypes. GLISTEN meeting 2015 – Allschwil, 01-02.04.2015, Allschwil, Switzerland, Book of abstracts, P44
  11. Hogendorf, A.S; Satała, G.; Staroń, J.; Warszycki, D.; Hogendorf, A.; Bugno, R.; Bojarski, A.J. Systematic study reveals new potent and selective 5-HT6R ligands based on indole scaffold. VIth Conversatory on Medicinal Chemistry, 18-20.09.2014, Lublin, Poland, Book of abstracts, p.21

Participation in research projects:

  • New non-amyloid treatment of cognitive disorders – NATCo, NCBiR PBS PBS3/B7/20/2015 executor 2015-
  • Innovative therapies for neurodegenerative and neurodevelopmental diseases based on mGlu receptor allosteric modulators – Allosterix, NCBiR 178469, executor 2014-