Adam Hogendorf

Adam Hogendorf, MSc

Adam Hogendorf, MSc
e-mail: ahogendorf@gmail.com

Research interests:

  • Total synthesis
  • Assymetric synthesis
  • Organometallic chemistry
  • Multicomponent reactions
  • Heterocyclic chemistry
  • Serotonin receptors research
  • Halogen bonding
  • Drug design

Scientific career:

  • from 10.2013 Jagiellonian University, Faculty of Chemistry, PhD studies
  • 2011–2013 Jagiellonian University, Faculty of Chemistry, the second level studies, course: chemistry, obtained degree: Master of Science (06.2013)
  • 2008–2011 Jagiellonian University, Faculty of Chemistry, the first level studies, course: chemistry, obtained degree: Bachelor of Science (06.2010)

Publications:

  1. Hogendorf, A. S.; Hogendorf, A.; Kurczab, R.; Satała, G.; Lenda, T.; Walczak, M.; Latacz, G.; Handzlik, J.; Kieć-Kononowicz, K.; Wierońska, J.; Woźniak, M.; Cieślik, P.; Bugno, R.; Staroń, J.; Bojarski, A. J. Low-basicity 5-HT7 Receptor Agonists Synthesized Using the van Leusen Multicomponent Protocol Sci. Rep. 2017, 7, Article number: 1444
    http://www.nature.com/articles/s41598-017-00822-4
  2. Staroń, J.; Mordalski, S.; Warszycki, D.; Satała, G.; Hogendorf, A. S.; Bojarski, A. J. Pyrano[2,3,4-cd]indole as a Scaffold for Selective Nonbasic 5-HT6R Ligands ACS Med. Chem. Lett.20178 (4), pp 390–3
  3. Rugor, A.; Tataruch, M.; Staroń, J.; Dudzik, A.; Niedzialkowska, E.; Nowak, P.; Hogendorf, A. S.; Michalik-Zym., A.; Naprószewska, D., B.; Jarzębski, A.; Szymańska, K.; Białas, W.; Szaleniec, M. Regioselective hydroxylation of cholecalciferol, cholesterol and its derivatives by Steroid C25 dehydrogenase. Appl. Microbiol. Biotechnol., 2016. (https://www.ncbi.nlm.nih.gov/pubmed/27726023)
  4. Staroń, J.; Warszycki, D.; Kurczab, R.; Satała, G.; Bugno, R.; Hogendorf, A. S.; Bojarski, A. J. Halogen bonding enhances activity in a series of dual 5-HT6/D2 ligands designed in a hybrid bioisostere generation/virtual screening protocol. RSC Adv., 2016, 6, 54918-54925 (http://pubs.rsc.org/en/content/articlelanding/2016/ra/c6ra08714k)
  5. Hogendorf, A. S.; Hogendorf, A.; Kurczab, R.; Satała, G.; Lenda, T.; Walczak, M.; Latacz, G.; Handzlik, J.; Kieć-Kononowicz, K.; Wierońska, J.; Woźniak, M.; Cieślik, P.; Bugno, R.; Staroń, J.; Bojarski, A. J. Low-basicity 5-HT7 Receptor Agonists Synthesized Using the van Leusen Multicomponent Protocol Sci. Rep. 2017, 7, Article number: 1444 (http://www.nature.com/articles/s41598-017-00822-4).
  6. Staroń, J.; Mordalski, S.; Warszycki, D.; Satała, G.; Hogendorf, A. S.; Bojarski, A. J. Pyrano[2,3,4-cd]indole as a Scaffold for Selective Nonbasic 5-HT6R Ligands ACS Med. Chem. Lett. 2017, 8(4), pp 390–394

Patent Applications:

  1. Hogendorf, A. S.; Stankiewicz, A.; Brański, P.; Burnat, G.; Bugno, R.; Hogendorf, A.; Trela, M.; Pilc, A.; Bojarski, A. J. The substituted indole- or indazole-based mGluR8-positive allosteric modulators and their medical use. EP16461558.5
  2. Hogendorf, A. S.; Hogendorf, A.; Bojarski, A. J.; Satała, G.; Kurczab, R; Lenda, T.; Bugno, R.; Staroń, J. Imidazolyl-substituted indole derivatives binding 5-HT7 serotonin receptor and pharmaceutical compositions thereof. EP16461543.7

Scientific reports:

a) posters:

  1. Hogendorf, A. S.; Hogendorf, A.; Kurczab, R.; Satała, G.; Lenda, T.; Latacz, G.; Bugno, R.; Staroń, J.; Bojarski, A. J. 3-(1-Alkyl-1H-imidazol-5-yl)-1H-indoles – selective 5-HT7 receptor agonists as potential PET radiotracers. Annual One-Day Meeting on Medicinal Chemistry of SRC & KVCV PET & Imaging : From Chemistry Lab to Clinical Applications, 18.11.2016, Mont-Saint-Guibert, Belgium, Book of abstracts, P13
  2. Hogendorf, A., S.; Hogendorf, A.; Kurczab, R.; Satała, G.; Lenda, T.; Latacz, G.; Bugno, R.; Staroń, J.; Bojarski, A. J. Low-basicity 5-HT7 agonists as potential molecular probes, PET-radiotracers or pharmacological drugs. XXIV EFMC International Symposium on Medicinal Chemistry, 28.08-01.09 2016, Manchester, England, Book of abstracts, P513
  3. Bugno, R.; Staroń, J.; Hogendorf, A. S.; Satała, G.; Warszycki, D.; Mordalski, S.; Bojarski, A. J. Design synthesis and structure-activity relationship of 1-(arylsulphonyl)-1H-indole derivatives as non-basic 5-HT6 receptor ligands. XXIV EFMC International Symposium on Medicinal Chemistry, 28.08-01.09 2016, Manchester, England, Book of abstracts, P299
  4. Hogendorf A. S.; Hogendorf, A.; Kurczab, R.; Satała, G.; Lenda, T.; Latacz, G.; Bugno, R.; Staroń. J.; Bojarski, A. J. Determining the binding mode of 3-(1-alkyl-1H-imidazol-5-yl)-1H-indoles. 3rd EFMC Young Medicinal Chemist Symposium, 01.09-03.09 2016, Manchester, England, Book of abstracts, FP16
  5. Hogendorf, A. S.; Hogendorf, A.; Kurczab, R.; Satała, G.; Lenda, T.; Latacz, G.; Bugno, R.; Staroń, J.; Bojarski, A. J. Low-basicity agonists of 5-HT7 receptor synthesized by van Leusen multicomponent reaction. VIII Conversatory on Medicinal Chemistry, 15.09-17.09.2016, Lublin, Poland, Book of abstracts, NS3
  6. Hogendorf, A.; Hogendorf, A. S.; Kurczab, R.; Satała, G.; Bojarski, A. J. Binding mode analysis of a series of novel 5-HT1A ligands. VIII Conversatory on Medicinal Chemistry, 15-17.09.2016, Lublin, Poland, Book of abstracts, P4
  7. Kurczab, R.; Hogendorf, A. S.; Staroń, J.; Canale, V.; Zajdel, P.; Bojarski, A. J. The potential of halogen bonding in class A of GPCRs: application of XB hot spots for rational design of 5-HT7R ligands. VIII Conversatory on Medicinal Chemistry, 15.09-17.09 2016, Lublin, Poland, Book of abstracts, C6
  8. Hogendorf, A.; Hogendorf, A. S.; Kurczab, R.; Satała, G.; Bojarski, A. J. Binding mode analysis of a series of novel 5-HT1A ligands. VIII Conversatory on Medicinal Chemistry, 15.09-17.09.2016, Lublin, Poland, Book of abstracts, P4
  9. Bugno, R.; Staroń, J.; Hogendorf, A. S.; Satała, G.; Warszycki, D.; Mordalski, S.; Bojarski, A. J. Synthesis and evaluation of a new indole-based series as non-basic 5-HT6 receptor ligands. VIII Conversatory on Medicinal Chemistry, 15.09-17.09.2016, Lublin, Poland, Book of abstracts, P95
  10. Pietruś, W.; Kurczab, R.; Hogendorf, A. S.; Bojarski, A. J. Exploring the influence of fluorine substitution on tuning the hydrogen bonding properties using theoretical and spectroscopic methods. VIII Conversatory on Medicinal Chemistry, 15.09-17.09.2016, Lublin, Polska, Book of abstracts, P107
  11. Mordalski, S.; Warszycki, D.; Staroń, J.; Hogendorf, A. S.; Bugno, R.; Satała, G.; Bojarski, A. J. Molecular mechanism of activity of non-basic ligands of 5-HT6 receptors. The 2nd Central European Biomedical Congress „From emerging biochemical strategies to personalized medicine”, 15-18.06.2016, Kraków, Poland, Book of abstracts S.12-1
  12. Brański, P.; Hogendorf, A. S.; Burnat, G.; Wierońska, J.; Chruścicka, B.; Chorobik, P.; Myszor, I.; Woźniak, M.; Bugno, R.; Bojarski, A. J.; Sylte, I.; Pilc, A. IP272050, a novel mGluR8 positive allosteric modulator. The 2nd Central European Biomedical Congress „From emerging biochemical strategies to personalized medicine”, 15-18.06.2016, Kraków, Poland, Book of abstracts P.5-13
  13. Staroń, J.; Warszycki, D.; Kurczab,R.; Satała, G.; Bugno, R.; Hogendorf, A. S.; Bojarski, A. J. Halogen bonding enhances affinity at 5-HT7R in a series of N-[2-(dimethylamine)ethyl]-N-(2-phenylehtyl)anilines. The 2nd Central European Biomedical Congress „From emerging biochemical strategies to personalized medicine”, 15-18.06.2016, Kraków, Poland, Book of abstracts, P135
  14. Hogendorf, A. S.; Brański, P.; Burnat, G.; Bugno, R.; Hogendorf, A.; Chruścicka, B.; Stankiewicz, A.; Trela, M.; Bojarski, A. J. Positive allosteric modulators of mGluR8: design and development. 6th EFMC International Symposium on Advances in Synthetic and Medicinal Chemistry, 15-18.11.2015, Rehovot, Israel, Book of abstracts, P040
  15. Hogendorf, A. S.; Brański, P.; Burnat, G.; Bugno, R.; Hogendorf, A.; Chruścicka, B.; Bojarski, A. J. The development of mGluR8 PAM agonists. VII Conversatory on Medicinal Chemistry, 17-19.09.2015, Lublin, Poland, Book of abstracts, PP13
  16. Hogendorf, A.; Hogendorf, A. S.; Bojarski, A. J. The synthesis of fused heterocyclic building blocks and their application as core structures of GPCR ligands. VII Conversatory on Medicinal Chemistry, 17-19.09.2015, Lublin, Poland, Book of abstracts, P42
  17. Bugno, R.; Staroń, J.; Hogendorf, A. S.; Satała, G.; Warszycki, D.; Mordalski, S.; Bojarski, A. J. New non-basic 5-HT6 Receptor Ligands. VII Conversatory on Medicinal Chemistry, 17-19.09.2015, Lublin, Poland, Book of abstracts, PP7
  18. Hogendorf, A. S.; Brański, P.; Burnat, G.; Bugno, R.; Hogendorf, A.; Chruścicka, B.; Bojarski, A. J. Finding allosteric modulators of metabotropic glutamate receptors as potential CNS drugs. V Meeting of the Paul Ehrlich MedChem Euro-PhD Network, 03-05.07.2015, Kraków, Poland, Book of abstracts, p.P-15
  19. Hogendorf, A. S.; Bugno,R.; Satała, G.; Hogendorf, A.; Staroń, J.; Warszycki, D.; Bojarski, A. J. Design and synthesis of aminergic GPCR’s ligands. Dokonania Naukowe Doktorantów III Edycja, 18.04.2015, Kraków, Poland, Book of abstracts, P24
  20. Hogendorf A. S.; Bojarski, A. J. Synthesis of indole derivatives as building blocks in organic and medicinal chemistry. Dokonania Naukowe Doktorantów III Edycja, 18.04.2015, Kraków, Poland, Book of abstracts, P23
  21. Hogendorf, A. S.; Satała, G.; Staroń, J.; Hogendorf, A.; Bugno, R.; Warszycki, D.; Bojarski, A. J. Three point pharmacophore investigation leads to novel serotonergic chemotypes. GLISTEN meeting 2015 – Allschwil, 01-02.04.2015, Allschwil, Switzerland, Book of abstracts, P44
  22. Hogendorf, A. S.; Staroń, J.; Bugno, R.; Satała, G.; Hogendorf, A.; Warszycki, D.; Bojarski, A., J. Development of new 5-HT6R ligand series illustrates the search for selective transmembrane proteins ligands; 2nd Polish Interdisciplinary Symposium Inter-Mix 2014, 20-23.11.2014, Wojanów, Poland, Book of abstracts, p.52
  23. Brański, P.; Hogendorf, A. S.; Burnat, G.; Bojarski, A. J.; Chruścicka, B.; Bugno, R.; Pilc, A. IP27039 a novel nonselective mGluR8 agonist?, 8th International Meeting on Metabotropic Glutamate Receptors, 29.09-03.10.2014, Taormina, Italy, Book of abstracts, p.24
  24. Hogendorf, A. S.; Satała, G. Synthesis and evaluation of new indole derivatives as aminergic GPCR ligands. Neuronus 2014 IBRO&IRUN Neuroscience Forum, 25-27.04.2014, Kraków, Poland, Book of abstracts, 7
  25. Hogendorf, A. S.; Hogendorf, A.; Kurczab, R.; Satała, G.; Lenda, T.; Walczak, M.; Latacz, G.; Handzlik, J.; Kieć-Kononowicz, K.; Wierońska, J.; Woźniak, M.; Cieślik, P.; Bugno, R.; Staroń, J.; Bojarski, A. J. New perspectives in serotonergic signal transduction studies. 3-(1-alkyl-1H-imidazol-5-yl)-1H-indoles, powerful tools to study the 5-HT7 receptor. EFMC-ASMC 2017, 27.08-01.09.2017, Vienna, Austria

a) speeches:

  1. Hogendorf, A. S.; Hogendorf, A.; Kurczab, R.; Satała, G.; Lenda, T.; Latacz, G.; Bugno, R.; Staroń, J.; Bojarski, A. J. Low-Basicity agonists of 5-HT7 receptor, synthesized by van Leusen multicomponent reaction. VIII Conversatory on Medicinal Chemistry, 15-17.09.2016, Lublin, Poland, Book of abstracts, NS3
  2. Hogendorf, A. S.; Satała, G.; Staroń, J.; Warszycki, D.; Hogendorf, A; Bugno, R.; Bojarski, A. J. Systematic study reveals new potent and selective 5-HT6R ligands based on indole scaffold. VIth Conversatory on Medicinal Chemistry, 18-20.09.2014, Lublin, Poland, Book of abstracts, p. 21

Participation in research projects:

  • EXtention of academia-based PLATFORM to antidepressant hits discovery (PLATFORMex), Pol-Nor/198887/73/2013, function: executor, 2013-
  • Innovative therapies for neurodegenerative and neurodevelopmental diseases based on mGlu receptor allosteric modulators – Allosterix, NCBiR 178469, executor 2013-
  • New non-amyloid treatment of cognitive disorders – NATCo, NCBiR PBS PBS3/B7/20/2015 executor 2015-
  • Nietypowe ligandy receptora 5-HT6 OPUS7 nr 2014/13/B/NZ7/02210, 2014-
  • Halogen bonding – the role and significance in interactions of ligands with class A GPCRs, SONATA, UMO-2014/15/D/NZ7/01782 executor 2015-